Albert Giralt

Hippocampal function in health and disease

ORCID Research Profile

Albert Giralt

Position: Principal Investigator

albertgiralt (at) ub.edu

Contact details

Dr. Albert Giralt

Department of Biomedicine

Faculty of Medicine, Casanova 143

08036 Barcelona (Spain)

932275400

albertgiralt (at) ub.edu

albert-giralt-lab.webnode.es

 

Current Research Lines

 

  • Research on new genetic risk factors in Alzheimer’s disease and study of new strategies for gene therapy in rodent models.
  • Research on the formation of neuronal engrams in murine models of depression induced by chronic stress.
  • Research on new risk factors for schizophrenia in murine models.

Technologies/Methods

 

  • Western blot
  • Immunofluorescence
  • Histological techniques
  • Electrophysiology in slices of brain. Induction of long-term potentiation (LTP).
  • Primary cultures of neural cells. Astrocytes, neurons, oligodendrocytes.
  • Biochemical tests: ELISA, enzymatic phosphatase and kinase activities
  • Advanced microscopy and confocal microscopy.
  • Stereotaxic surgery in animals (mice and rats).
  • Implantation of intracerebral osmotic pumps and pumps in mice and rats.
  • Techniques of molecular biology. RT-PCR and PCR.
  • Behavioral characterization of mouse models.

Highlighted Publications

 

De Pins B, Cifuentes-Díaz C, Farah AT, López-Molina L, Montalban E,
Sancho-Balsells A, López A, Ginés S, Delgado-García JM, Alberch J, Gruart A,
Girault JA, Giralt A. Conditional BDNF Delivery from Astrocytes Rescues Memory
Deficits, Spine Density, and Synaptic Properties in the 5xFAD Mouse Model of
Alzheimer Disease. J Neurosci. 2019 Mar 27;39(13):2441-2458.

 

Montalban E, Al-Massadi O, Sancho-Balsells A, Brito V, de Pins B, Alberch J,
Ginés S, Girault JA, Giralt A. Pyk2 in the amygdala modulates chronic stress
sequelae via PSD-95-related micro-structural changes. Transl Psychiatry. 2019 Jan
15;9(1):3.

 

Giralt A, de Pins B, Cifuentes-Díaz C, López-Molina L, Farah AT, Tible M,
Deramecourt V, Arold ST, Ginés S, Hugon J, Girault JA. PTK2B/Pyk2 overexpression
improves a mouse model of Alzheimer’s disease. Exp Neurol. 2018 Sep;307:62-73.

 

Giralt A, Brito V, Chevy Q, Simonnet C, Otsu Y, Cifuentes-Díaz C, de Pins B,
Coura R, Alberch J, Ginés S, Poncer JC, Girault JA. Pyk2 modulates hippocampal
excitatory synapses and contributes to cognitive deficits in a Huntington’s
disease model. Nat Commun. 2017 May 30;8:15592.

 

Giralt A, Coura R, Girault JA. Pyk2 is essential for astrocytes mobility
following brain lesion. Glia. 2016 Apr;64(4):620-34. doi: 10.1002/glia.22952.
Epub 2015 Dec 11. PubMed PMID: 26663135.