BIPOLAR DISORDER

Principal Investigators

Eduard Vieta

Full Professor

Bipolar disorder

Research team

 

Antoni Benabarre

Medical Assistant Professor

 

Iria Grande

Medical Assistant Professor

 

Jose Manuel Goikolea

Medical Assistant Professor

 

Ana Isabel Martinez

Medical Assistant Professor

 

Marina Garriga

Postdoctoral Researcher

 

Diego Hidalgo

Postdoctoral Researcher

 

Ester Jimenez

Postdoctoral Researcher

 

Andrea Murru

Postdoctoral Researcher

 

Isabella Pacchiarotti

Postdoctoral researcher

 

Carla Torrent

Postdoctoral researcher

 

Marc Valenti

Postdoctoral researcher

 

Norma Verdolini

Postdoctoral researcher

 

Gerard Anmella

Early Stage Researcher

 

Derek Clougher

Early Stage Researcher

 

Giovanna Fico

Early Stage Researcher

 

Anna Gimenez

Early Stage Researcher

 

Susana Gomes-da-Costa

Early Stage Researcher

 

Maria Sague

Early Stage Researcher

 

Laura Montejo

Early Stage Researcher

 

Estela Salagre

Early Stage Researcher

 

Jose Sanchez

Early Stage Researcher

 

Brisa Sole

Early Stage Researcher

 

Cristina Varo

Early Stage Researcher

Research Interest

 

The bipolar and depressive disorders programme, characterised by a multidisciplinary approach, investigates the neurobiological and anatomofunctional mechanisms involved in the development of the disease (genetics, neuromodulators, hormone factors and neuroimaging) and its relapses, the clinical course and neuropsychological consequences, the efficacy of drug treatments and novel therapies, and psychological interventions for the early detection and relapse prevention, the therapeutic adherence enhancement; and the improvement of the effectiveness of therapeutic strategies for affective disorders.

 

Its strategic objectives are to investigate the causes and mechanisms involved in the etiopathogenesis of bipolar and unipolar disorders and to investigate new treatments to improve the prognosis of these diseases.

Technologies & Methods

 

  • Psychiatric assessment and treatment
  • Clinical trial design and methodology

Active Projects

 

    • A New Intervention for Implementation of Pharmacogenetics in Psychiatry. European Union. 945151. Eduard Vieta.

 

    • Early intervention to improve cognitive reserve in subjects at risk and early stages of phychosis. Fundació Clínic. FCRB_ PB2_2020. Eduard Vieta.

 

    • Estancia de formación en medicina de precisión en el trastorno bipolar. Creación de modelos predictivos de diagnóstico de trastorno bipolar y respuesta al tratamiento a partir de registros nacionales. Instituto de Salud Carlos III. MV20/00018. Eduard Vieta.

 

    • Estudio sobre la eficacia de un abordaje psicológico para la potenciación de la reserva cognitiva en población bipolar con un primer episodio reciente. Ministerio de Economia y Competitividad. PI18/00805. Eduard V

 

    • Optimizing response to Li treatment through personalized evaluation of individuals with bipolar I disorder: the R-LiNK initiative. European Union. SC1-PM-02-2017. 754907-1. Eduard Vieta.

 

    • Recovery with MIND/COVID-19: Development, feasibility and effectiveness of a smartphone application (PRESTOapp) for mental health problems in health workers during the COVID-19 pandemic. Fundación Española de Psiquiatría y Salud Mental. FEPSM_COVID19_20_1. Eduard Vieta.

 

    • Salud Mental (CIBERSAM). Ministerio de Sanidad y Consumo. CB07/09/0004. Eduard Vieta.ieta.

Selected Publications

 

    • Alonso, J., Vilagut, G., Mortier, P., Ferrer, M., Alayo, I., Aragón- Peña, A., Aragonès, E., Campos, M., Cura-González, I. D., Emparanza, J. I., Espuga, M., Forjaz, M. J., González-Pinto, A., Haro, J. M., López-Fresneña, N., Salázar, A., Molina, J. D., Ortí-Lucas, R. M., Parellada, M., Pelayo-Terán, J. M., … MINDCOVID Working group (2021). Mental health impact of the first wave of COVID-19 pandemic on Spanish healthcare workers: A large cross-sectional survey. Revista de Psiquiatria y Salud Mental, 14(2), 90–105. https://doi.org/10.1016/j.rpsm.2020.12.001

 

    • Amare, A. T., Schubert, K. O., Hou, L., Clark, S. R., Papiol, S., Cearns, M., Heilbronner, U., Degenhardt, F., Tekola-Ayele, F., Hsu, Y. H., Shekhtman, T., Adli, M., Akula, N., Akiyama, K., Ardau, R., Arias, B., Aubry, J. M., Backlund, L., Bhattacharjee, A. K., Bellivier, F., … Baune, B. T. (2021). Association of polygenic score for major depression with response to lithium in patients with bipolar disorder. Molecular Psychiatry, 26(6), 2457–2470. https://doi.org/10.1038/s41380-020-0689-5

 

    • Andlauer, T. F. M., Guzman-Parra, J., Streit, F., Strohmaier, J., González, M. J., Gil Flores, S., Cabaleiro Fabeiro, F. J., del Río Noriega, F., Perez, F. P., Haro González, J., Orozco Diaz, G., de Diego-Otero, Y., Moreno-Küstner, B., Auburger, G., Degenhardt, F., Heilmann-Heimbach, S., Herms, S., Hoffmann, P., Frank, J., … Consortium, B. D. W. G. of the P. G. (2021). Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders. Molecular Psychiatry, 26(4), 1286–1298. https://doi.org/10.1038/s41380-019-0558-2

 

    • Antonietta Furio, M., Popovic, D., Vieta, E., Stukalin, Y., Hagin, M., Torrent, C., Azorin, J. M., Angst, J., Bowden, C. L., Mosolov, S., Young, A. H., Perugi, G., & BRIDGE-II-Mix Study Group (2021). Characterization of rapid cycling bipolar patients presenting with major depressive episode within the BRIDGE-II-MIX study. Bipolar Disorders, 23(4), 391–399. https://doi.org/10.1111/bdi.12994

 

    • Crovetto, F., Crispi, F., Casas, R., Martín-Asuero, A., Borràs, R., Vieta, E., Estruch, R., Gratacós, E., & IMPACT BCN Trial Investigators (2021). Effects of Mediterranean Diet or Mindfulness-Based Stress Reduction on Prevention of Smallfor-Gestational Age Birth Weights in Newborns Born to At-Risk Pregnant Individuals: The IMPACT BCN Randomized Clinical Trial. JAMA, 326(21), 2150–2160. https://doi.org/10.1001/jama.2021.20178

 

    • Kalman, J. L., Olde Loohuis, L. M., Vreeker, A., McQuillin, A., Stahl, E. A., Ruderfer, D., Grigoroiu-Serbanescu, M., Panagiotaropoulou, G., Ripke, S., Bigdeli, T. B., Stein, F., Meller, T., Meinert, S., Pelin, H., Streit, F., Papiol, S., Adams, M. J., Adolfsson, R., Adorjan, K., Agartz, I., … Ophoff, R. A. (2021). Characterisation of age and polarity at onset in bipolar disorder. British Journal of Psychiatry, 219(6), 659–669. https://doi.org/10.1192/bjp.2021.102

 

    • Kessing, L. V., González-Pinto, A., Fagiolini, A., Bechdolf, A., Reif, A., Yildiz, A., Etain, B., Henry, C., Severus, E., Reininghaus, E. Z., Morken, G., Goodwin, G. M., Scott, J., Geddes, J. R., Rietschel, M., Landén, M., Manchia, M., Bauer, M., Martinez- Cengotitabengoa, M., Andreassen, O. A., … Vieta, E. (2021). DSM-5 and ICD-11 criteria for bipolar disorder: Implications for the prevalence of bipolar disorder and validity of the diagnosis – A narrative review from the ECNP bipolar disorders network. European Neuropsychopharmacology, 47, 54–61. https://doi.org/10.1016/j.euroneuro.2021.01.097

 

    • Kupka, R., Duffy, A., Scott, J., Almeida, J., Balanzá-Martínez, V., Birmaher, B., Bond, D. J., Brietzke, E., Chendo, I., Frey, B. N., Grande, I., Hafeman, D., Hajek, T., Hillegers, M., Kauer-Sant’Anna, M., Mansur, R. B., van der Markt, A., Post, R., Tohen, M., Tremain, H., … Kapczinski, F. (2021). Consensus on nomenclature for clinical staging models in bipolar disorder: A narrative review from the International Society for Bipolar Disorders (ISBD) Staging Task Force. Bipolar Disorders, 23(7), 659–678. https://doi.org/10.1111/bdi.13105

 

    • McAllister-Williams, R. H., Arango, C., Blier, P., Demyttenaere, K., Falkai, P., Gorwood, P., Hopwood, M., Javed, A., Kasper, S., Malhi, G. S., Soares, J. C., Vieta, E., Young, A. H., Papadopoulos, A., & Rush, A. J. (2021). Reconceptualising treatment-resistant depression as difficult-to-treat depression. Lancet. Psychiatry, 8(1), 14–15. https://doi.org/10.1016/S2215-0366(20)30516-2

 

    • McWhinney, S. R., Abé, C., Alda, M., Benedetti, F., Bøen, E., Del Mar Bonnin, C., Borgers, T., Brosch, K., Canales-Rodríguez, E. J., Cannon, D. M., Dannlowski, U., Diaz-Zuluaga, A. M., Dietze, L., Elvsåshagen, T., Eyler, L. T., Fullerton, J. M., Goikolea, J. M., Goltermann, J., Grotegerd, D., Haarman, B., … ENIGMA Bipolar Disorders Working Group (2021). Diagnosis of bipolar disorders and body mass index predict clustering based on similarities in cortical thickness-ENIGMA study in 2436 individuals. Bipolar Disorders, 10.1111/bdi.13172. https://doi.org/10.1111/bdi.13172

 

    • Pinzón-Espinosa, J., Valdés-Florido, M. J., Riboldi, I., Baysak, E., Vieta, E., & EFPT Psychiatry Across Borders Working Group (2021). The COVID-19 Pandemic and Mental Health of Refugees, Asylum Seekers, and Migrants. Journal of Affective Disorders, 280(Pt A), 407–408. https://doi.org/10.1016/j.jad.2020.11.029

 

    • Sugranyes, G., de la Serna, E., Ilzarbe, D., Pariente, J. C., Borras, R., Romero, S., Rosa, M., Baeza, I., Moreno, M. D., Bernardo, M., Vieta, E., & Castro-Fornieles, J. (2021). Brain structural trajectories in youth at familial risk for schizophrenia or bipolar disorder according to development of psychosis spectrum symptoms. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 62(6), 780–789. https://doi.org/10.1111/jcpp.13321

 

    • Writing Committee for the Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Bipolar Disorder, Major Depressive Disorder, Obsessive-Compulsive Disorder, and Schizophrenia ENIGMA Working Groups, Patel, Y., Parker, N., Shin, J., Howard, D., French, L., Thomopoulos, S. I., Pozzi, E., Abe, Y., Abé, C., Anticevic, A., Alda, M., Aleman, A., Alloza, C., Alonso-Lana, S., … Paus, T. (2021). Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders. JAMA Psychiatry, 78(1), 47–63. https://doi.org/10.1001/jamapsychiatry.2020.2694

 

    • Yatham, L. N., Chakrabarty, T., Bond, D. J., Schaffer, A., Beaulieu, S., Parikh, S. V., McIntyre, R. S., Milev, R. V., Alda, M., Vazquez, G., Ravindran, A. V., Frey, B. N., Sharma, V., Goldstein, B. I., Rej, S., O’Donovan, C., Tourjman, V., Kozicky, J. M., Kauer-Sant’Anna, M., Malhi, G., … Post, R. (2021). Canadian Network for Mood and Anxiety Treatments (CANMAT) and International Society for Bipolar Disorders (ISBD) recommendations for the management of patients with bipolar disorder with mixed presentations. Bipolar Disorders, 23(8), 767–788. https://doi.org/10.1111/bdi.13135

Knowledge transfer & Innovation

 

  • Premi Josep Trueta 2021. L’Acadèmia de Ciències Mèdiques i
    de la Salut de Catalunya i de Balears. Eduard Vieta.