BIPOLAR DISORDER

Principal Investigators

Eduard Vieta

Full Professor

Bipolar disorder

Research team

 

Antoni Benabarre

Medical Assistant Professor

 

Iria Grande

Medical Assistant Professor

 

Jose Manuel Goikolea

Medical Assistant Professor

 

Ana Isabel Martinez

Medical Assistant Professor

 

Marina Garriga

Postdoctoral Researcher

 

Diego Hidalgo

Postdoctoral Researcher

 

Ester Jimenez

Postdoctoral Researcher

 

Andrea Murru

Postdoctoral Researcher

 

Isabella Pacchiarotti

Postdoctoral researcher

 

Carla Torrent

Postdoctoral researcher

 

Marc Valenti

Postdoctoral researcher

 

Norma Verdolini

Postdoctoral researcher

 

Gerard Anmella

Early Stage Researcher

 

Derek Clougher

Early Stage Researcher

 

Giovanna Fico

Early Stage Researcher

 

Anna Gimenez

Early Stage Researcher

 

Susana Gomes-da-Costa

Early Stage Researcher

 

Maria Sague

Early Stage Researcher

 

Laura Montejo

Early Stage Researcher

 

Estela Salagre

Early Stage Researcher

 

Jose Sanchez

Early Stage Researcher

 

Brisa Sole

Early Stage Researcher

 

Cristina Varo

Early Stage Researcher

Research Interest

 

The bipolar disorder programme, characterised by a multidisciplinary approach, investigates the neurobiological and anatomofunctional mechanisms involved in the development and clinical course of the disease, comorbidity, neurocognitive mechanisms, and the search for new pharmacologic, biophysical and psychosocial treatments, within the paradigm of personalised medicine as applied to mental health.

Technologies & Methods

 

  • Psychiatric assessment and treatment
  • Clinical trial design and methodology

Featured Projects

 

    • A New Intervention for Implementation of Pharmacogenetics in Psychiatry (PSY-PGx). European Union. 945151. Eduard Vieta

 

    • Caracterització dels pròdroms i detecció de factors predictors pronòstics en una mostra de pacients bipolars amb un primer episodi maniac. Departament de Salut de la Generalitat de Catalunya. SLT006/17/00357. Eduard Vieta

 

    • Eficacia de la Rehabilitación Funcional adaptada a pacientes con primeros episodios psicóticos coadyuvante al tratamiento farmacológico versus tratamiento farmacológico habitual (FROzEN). Ministerio de Economia y Competitividad. PI18/00789. Ana Isabel Martinez

 

    • Estudio sobre la eficacia de un abordaje psicológico para la potenciación de la reserva cognitiva en población bipolar con un primer episodio reciente. Ministerio de Economia y Competitividad. PI18/00805. Eduard Vieta

 

    • Optimizing response to Li treatment through personalized evaluation of individuals with bipolar I disorder: the R-LiNK initiative. European Union. 754907-1. Eduard Vieta

Featured Publications

 

    • Andlauer, T., Guzman-Parra, J., Streit, F., Strohmaier, J., González, M. J., Gil Flores, S., Cabaleiro Fabeiro, F. J., Del Río Noriega, F., Perez, F. P., Haro González, J., Orozco Diaz, G., de Diego-Otero, Y., Moreno-Küstner, B., Auburger, G., Degenhardt, F., Heilmann-Heimbach, S., Herms, S., Hoffmann, P., Frank, J., Foo, J. C., … Rietschel, M. (2021). Bipolar multiplex families have an increased burden of common risk variants for psychiatric disorders. Molecular Psychiatry, 26(4), 1286–1298. https://doi.org/10.1038/s41380-019-0558-2

 

    • Writing Committee for the Attention-Deficit/Hyperactivity Disorder, Autism Spectrum Disorder, Bipolar Disorder, Major Depressive Disorder, Obsessive-Compulsive Disorder, and Schizophrenia ENIGMA Working Groups, Patel, Y., Parker, N., Shin, J., Howard, D., French, L., Thomopoulos, S. I., Pozzi, E., Abe, Y., Abé, C., Anticevic, A., Alda, M., Aleman, A., Alloza, C., Alonso-Lana, S., … Paus, T. (2021). Virtual Histology of Cortical Thickness and Shared Neurobiology in 6 Psychiatric Disorders. JAMA Psychiatry, 78(1), 47–63. https://doi.org/10.1001/jamapsychiatry.2020.2694

 

    • Amare, A. T., Schubert, K. O., Hou, L., Clark, S. R., Papiol, S., Cearns, M., Heilbronner, U., Degenhardt, F., Tekola-Ayele, F., Hsu, Y. H., Shekhtman, T., Adli, M., Akula, N., Akiyama, K., Ardau, R., Arias, B., Aubry, J. M., Backlund, L., Bhattacharjee, A. K., Bellivier, F., … Baune, B. T. (2020). Association of polygenic score for major depression with response to lithium in patients with bipolar disorder. Molecular Psychiatry, 10.1038/s41380-020-0689-5. Advance online publication. https://doi.org/10.1038/s41380-020-0689-5

 

 

    • Han, L., Dinga, R., Hahn, T., Ching, C., Eyler, L. T., Aftanas, L., Aghajani, M., Aleman, A., Baune, B. T., Berger, K., Brak, I., Filho, G. B., Carballedo, A., Connolly, C. G., Couvy-Duchesne, B., Cullen, K. R., Dannlowski, U., Davey, C. G., Dima, D., Duran, F., … Schmaal, L. (2020). Brain aging in major depressive disorder: results from the ENIGMA major depressive disorder working group. Molecular Psychiatry, 10.1038/s41380-020-0754-0. Advance online publication. https://doi.org/10.1038/s41380-020-0754-0

 

    • Moreno, C., Wykes, T., Galderisi, S., Nordentoft, M., Crossley, N., Jones, N., Cannon, M., Correll, C. U., Byrne, L., Carr, S., Chen, E., Gorwood, P., Johnson, S., Kärkkäinen, H., Krystal, J. H., Lee, J., Lieberman, J., López-Jaramillo, C., Männikkö, M., Phillips, M. R., … Arango, C. (2020). How mental health care should change as a consequence of the COVID-19 pandemic. The Lancet Psychiatry, 7(9), 813–824. https://doi.org/10.1016/S2215-0366(20)30307-2

 

    • Radua, J., Vieta, E., Shinohara, R., Kochunov, P., Quidé, Y., Green, M. J., Weickert, C. S., Weickert, T., Bruggemann, J., Kircher, T., Nenadić, I., Cairns, M. J., Seal, M., Schall, U., Henskens, F., Fullerton, J. M., Mowry, B., Pantelis, C., Lenroot, R., Cropley, V., … ENIGMA Consortium collaborators (2020). Increased power by harmonizing structural MRI site differences with the ComBat batch adjustment method in ENIGMA. NeuroImage, 218, 116956. https://doi.org/10.1016/j.neuroimage.2020.116956

 

    • Solé, B., Bonnín, C. M., Radua, J., Montejo, L., Hogg, B., Jimenez, E., Reinares, M., Valls, E., Varo, C., Pacchiarotti, I., Valentí, M., Garriga, M., Torres, I., Martínez-Arán, A., Vieta, E., & Torrent, C. (2020). Long-term outcome predictors after functional remediation in patients with bipolar disorder. Psychological Medicine, 1–9. Advance online publication. https://doi.org/10.1017/S0033291720001968

 

    • Miskowiak, K. W., Seeberg, I., Kjaerstad, H. L., Burdick, K. E., Martinez-Aran, A., Del Mar Bonnin, C., Bowie, C. R., Carvalho, A. F., Gallagher, P., Hasler, G., Lafer, B., López-Jaramillo, C., Sumiyoshi, T., McIntyre, R. S., Schaffer, A., Porter, R. J., Purdon, S., Torres, I. J., Yatham, L. N., Young, A. H., … Vieta, E. (2019). Affective cognition in bipolar disorder: A systematic review by the ISBD targeting cognition task force. Bipolar Disorders, 21(8), 686–719. https://doi.org/10.1111/bdi.12834

 

    • Cross-Disorder Group of the Psychiatric Genomics Consortium. Electronic address: plee0@mgh.harvard.edu, & Cross-Disorder Group of the Psychiatric Genomics Consortium (2019). Genomic Relationships, Novel Loci, and Pleiotropic Mechanisms across Eight Psychiatric Disorders. Cell, 179(7), 1469–1482.e11. https://doi.org/10.1016/j.cell.2019.11.020