Principal Investigators

Josefina Castro-Fornieles

Full Professor

Child and adolescent psychiatry and psychology

Research team


Susana Andres

Medical Assistant Professor


Inmaculada Baeza

Medical Assistant Professor


Rosa Calvo

Medical Assistant Professor


Maria Luisa Lazaro

Medical Assistant Professor


Astrid Morer

Medical Assistant Professor


Olga Puig

Medical Assistant Professor


Ana Blazquez

Postdoctoral Researcher


Itziar Flamarique

Postdoctoral researcher


Sara Lera

Postdoctoral researcher


Ana Encarnacion Ortiz

Postdoctoral researcher


Ana Perez

Postdoctoral researcher


Maria Teresa Plana

Postdoctoral researcher


Soledad Romero

Postdoctoral researcher


Mireia Rosa

Postdoctoral researcher


Pilar Santamarina

Postdoctoral researcher


Elena de la Serna

Postdoctoral researcher


Gisela Sugranyes

Postdoctoral researcher


Patricia Camprodon

Postdoctoral researcher


Blanca Garcia



Daniel Ilzarbe


Research Interest


The presence of psychiatric and psychological disorders is observed in approximately 15% of children and adolescents. Studying the disorders’ characteristics at these ages is important to establish an early diagnosis and intervention in order to improve their prognosis. This programme investigates the genetic bases and clinical, cognitive, and neuroimaging characteristics of the most prevalent psychiatric and psychological diseases in children and adolescents: disorders related to eating, depression, anxiety, emotional upsets, attention deficit and hyperactivity, autistic disorders and psychotic disorders, among others.

Technologies & Methods


  • Neuroimaging
  • Genetics

Featured Projects


    • A phase ib, multicenter, open-label, 6-week study with a 48-week extension to investigate the pharmacokinetics, safety, and tolerability of balovaptan in children ages 2–4 years with autism spectrum disorder. 2019-000989-38. Luisa Lazaro


    • A translational model of autoimmune synaptopathy: symptoms, brain networks, and the link to human memory. Instituto de Salud Carlos III. Ministerio de Economia y Competitividad. PIE16/00014. Josefina Castro-Fornieles


    • Autism innovative medicine studies-2-trials. European Union. H2020-BBIJTI-2016-777394. Rosa Maria Calvo


    • Characterization by neuroimage of predictors and mechanisms of response to cognitive-behavioral therapy in obsessive-compulsive disorder. PERIS. SLT006/17/00249. Joaquim Radua i Luisa Lazaro


    • Clinical, cognitive and neuroimaging characteristics of child and adolescent offspring of patients diagnosed with schizophrenia and ADHD. Instituto de Salud Carlos III. Ministerio de Economia y Competitividad. PI18/00696. Josefina Castro-Fornieles


    • Construction of a multimodal model with diagnostic and prognostic capacity in adolescents at high risk of psychosis: integration of genetic, environmental and neuroimaging factors. PI18/00976. Gisela Sugranyes


    • Detection of the risk of schizophrenia using PGRS in children and adolescents of patients with schizophrenia or bipolar disorder. Instituto de Salud Carlos III. Ministerio de Economia y Competitividad. Josefina Castro-Fornieles


    • Effect of adjuvant treatment with N-Acetylcysteine for 48 weeks on gray matter loss and oxidative metabolism in patients with early-onset first psychotic episodes: Randomized, double-blind, placebo-controlled clinical trial. 2012-005435-87. Josefina Castro-Fornieles


    • Eight-year follow-up of children and adolescents offspring of patients diagnosed with schizophrenia or bipolar disorder. Instituto de Salud Carlos III. Ministerio de Economia y Competitividad. PI15/00467. Josefina Castro-Fornieles


    • From the synapse to brain structure and function: a comparative study between youth with early stage psychosis and patients with NMDA receptor encephalitis. Brain & Behaviour Research foundation. Gisela Sugranyes


    • Influence of genetics and epigenetics on the efficacy of the treatment of Obsessive-Compulsive disorder with cognitive-behavioral therapy or pharmacological treatment. Instituto de Salud Carlos III. Ministerio de Economia y Competitividad. PI16/01086. Luisa Lazaro


    • Influence of vaccines, infectious and immunological biomarkers and analysis of transcriptome-interactome networks in the course of tic disorders: a longitudinal study. Instituto de Salud Carlos III. Ministerio de Economia y Competitividad. PI20/01056. Astrid Morer


    • Longitudinal multicenter study on the role of neurobiological markers of stress in children and adolescents with psychosis risk syndrome and the transition to psychosis. Instituto de Salud Carlos III. Ministerio de Economia y Competitividad. PI15/00444. Inmaculada Baeza


    • Longitudinal study of nutritional and stress markers in children adn adolescents diagnosed with psychosis risk syndrome and the predictive capacity in transition to psychosis. Ministerio de Economia y Competitividad. PI18/00242. Inmaculada Baeza


    • Mother-baby day hospital: effectiveness of intensive multidisciplinary intervention for women with perinatal mental disorder. Susana Andres


    • Phenomenology and neuroimmune pathways of repetitive and restrictive behaviors. Instituto de Salud Carlos III. Ministerio de Economia y Competitividad. PI19/01122. Luisa Lazaro


    • Placebo-controlled trial in subjects at ultra high risk for psychosis with omega-3 fatty acids in Europe (PURPOSE). IBP-FLU-2017-O1. Inmaculada Baeza


    • Randomized, double-blind, placebo-controlled psychoactive study to evaluate the efficacy and safety of three fixed doses (28, 56 and 84 mg) of intranasal esketamine in conjunction with conventional comprehensive care in the rapid reduction of symptoms of major depressive disorder, including suicidal ideation, in pediatric subjects considered at risk of imminent suicide. ESKETINSUI 2002. 2016-004422-42. Luisa Lazaro


    • Study on the efficacy of cognitive reserve enhancement in children, adolescents and young adults at high genetic risk for schizophrenia or bipolar disorder. Instituto de Salud Carlos III. Ministerio de Economia y Competitividad. PI17/00741. Elena de la Serna


    • Why can’t the child stop washing? Learning habits in childhood TOC. Fundation Alicia Koplowitz. Rosa Calvo Escalona

Featured Publications


    • Santamarina-Perez, P., Mendez, I., Singh, M. K., Berk, M., Picado, M., Font, E., Moreno, E., Martínez, E., Morer, A., Borràs, R., Cosi, A., & Romero, S. (2020). Adapted Dialectical Behavior Therapy for Adolescents with a High Risk of Suicide in a Community Clinic: A Pragmatic Randomized Controlled Trial. Suicide & Life-Threatening Behavior, 50(3), 652–667.


    • Sugranyes, G., de la Serna, E., Ilzarbe, D., Pariente, J. C., Borras, R., Romero, S., Rosa, M., Baeza, I., Moreno, M. D., Bernardo, M., Vieta, E., & Castro-Fornieles, J. (2020). Brain structural trajectories in youth at familial risk for schizophrenia or bipolar disorder according to development of psychosis spectrum symptoms. Journal of Child Psychology and Psychiatry, and Allied Disciplines, 10.1111/jcpp.13321. Advance online publication.


    • Puig, O., Fisher, M., Loewy, R., Miley, K., Ramsay, I. S., Carter, C. S., Ragland, J. D., Niendam, T., & Vinogradov, S. (2020). Early- Versus Adult-Onset Schizophrenia as a Predictor of Response to Neuroscience-Informed Cognitive Training. Journal of Clinical Psychiatry, 81(2), 18m12369.


    • Vilaplana-Pérez, A., Pérez-Vigil, A., Sidorchuk, A., Brander, G., Isomura, K., Hesselmark, E., Kuja-Halkola, R., Larsson, H., Mataix-Cols, D., & Fernández de la Cruz, L. (2020). Much more than just shyness: the impact of social anxiety disorder on educational performance across the lifespan. Psychological Medicine, 1–9. Advance online publication.


    • De la Serna, E., Camprodon-Boadas, P., Ilzarbe, D., Sugranyes, G., Baeza, I., Moreno, D., Díaz-Caneja, C. M., Rosa-Justicia, M., Llorente, C., Ayora, M., Borras, R., Torrent, C., Bernardo, M., & Castro-Fornieles, J. (2020). Neuropsychological development in the child and adolescent offspring of patients diagnosed with schizophrenia or bipolar disorder: A two-year follow-up comparative study. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 103, 109972.


    • Cervin, M., Lázaro, L., Martínez-González, A. E., Piqueras, J. A., Rodríguez-Jiménez, T., Godoy, A., Aspvall, K., Barcaccia, B., Pozza, A., & Storch, E. A. (2020). Obsessive-compulsive symptoms and their links to depression and anxiety in clinic- and community-based pediatric samples: A network analysis. Journal of Affective Disorders, 271, 9–18.


    • Ariño, H., Muñoz-Lopetegi, A., Martinez-Hernandez, E., Armangue, T., Rosa-Justicia, M., Escudero, D., Matos, N., Graus, F., Sugranyes, G., Castro-Fornieles, J., Compte, A., Dalmau, J., & Santamaria, J. (2020). Sleep disorders in anti-NMDAR encephalitis. Neurology, 95(6), e671–e684.


    • Rodríguez, N., Morer, A., González-Navarro, E. A., Serra-Pages, C., Boloc, D., Torres, T., Martinez-Pinteño, A., Mas, S., Lafuente, A., Gassó, P., & Lázaro, L. (2019). Altered frequencies of Th17 and Treg cells in children and adolescents with obsessive-compulsive disorder. Brain, Behavior, and Immunity, 81, 608–616.


    • Castro-Fornieles, J., de la Serna, E., Calvo, A., Pariente, J., Andrés-Perpiña, S., Plana, M. T., Romero, S., Flamarique, I., Gárriz, M., & Bargalló, N. (2019). Cortical thickness 20 years after diagnosis of anorexia nervosa during adolescence. European Archives of Psychiatry and Clinical Neuroscience, 10.1007/s00406-019-00992-4. Advance online publication.


    • Ilzarbe, D., de la Serna, E., Baeza, I., Rosa, M., Puig, O., Calvo, A., Masias, M., Borras, R., Pariente, J. C., Castro-Fornieles, J., & Sugranyes, G. (2019). The relationship between performance in a theory of mind task and intrinsic functional connectivity in youth with early onset psychosis. Developmental Cognitive Neuroscience, 40, 100726.