CLINICAL RESEARCH IN ALZHEIMER’S DISEASE AND OTHER COGNITIVE DISORDERSS

Principal Investigators

RAQUEL SANCHEZ-VALLE

Neurologist

Clinical research in Alzheimer’s disease and other cognitive disorders

Research team

 

Anna Antonell

Postdoctoral Researcher

 

Beatriz Bosch

Postdoctoral Researcher

 

Lorena Rami

Postdoctoral Researcher

 

Sergi Borrego

Early Stage Researcher

 

Jose Miguel Contador

Early Stage Researcher

 

Neus Falgas

Early Stage Researcher

 

Agnes Perez

Early Stage Researcher

 

Oscar Ramos

Early Stage Researcher

 

Adria Tort

Early Stage Researcher

 

Jaume Olives

Project Manager

 

Mircea Balasa

Others

 

Magda Castellvi

Others

 

Guadalupe Fernandez

Others

 

Albert Llado

Others

 

Nuria Montagut

Others

Research Interest

 

This programme is devoted to the diagnosis and intervention, research and education in the field of neurodegenerative cognitive disorders and dementia. In addition, the group collaborates with pharmaceutical companies in the study of new drugs for the treatment of patients with cognitive problems (pharmacological clinical trials). The main interests are: investigations on clinical, molecular and imaging biomarkers that characterise the preclinical/predementia phases of Alzheimer disease and other neurodegenerative cognitive disorders; and investigation of biological pathways involved in the pathogenesis of neurodegenerative dementias.

Technologies & Methods

 

  • Neuropsychological testing for early cognitive changes
  • Neuroimaging: structural and functional MRI
  • Blood and CSF biochemical markers
  • Genetic counseling and genetic testing

Featured Projects

 

    • Contratos de formación en investigación ”Rio Hortega” (Post Formación Sanitaria Especializada). Instituto de Salud Carlos III. CM18/00028. Raquel Sanchez-Valle

 

    • Dominantly Inherited Alzheimer Network (DIAN). National Institutes of Health (NIH). UF1 AG032438. Raquel Sanchez-Valle

 

    • Estudio de biomarcadores y desarrollo de nuevas estrategias terapéuticas en una cohorte multicéntrica de Demencia Frontotemporal. Departament de Salut de la Generalitat de Catalunya. SLT002/16/00408. Raquel Sanchez-Valle

 

    • Genetic dementias (genetic Alzheimer’s disease, frontotemporal dementia and prion diseases): longitudinal changes and expression and epigenetic differences with sporadic cases. Instituto de Salud Carlos III. AES2020-PI 20/00448. Raquel Sánchez-Valle. 176.660€. 01/01/2021-31/12/2023

Featured Publications

 

    • Falgàs, N., Tort-Merino, A., Balasa, M., Borrego-Écija, S., Castellví, M., Olives, J., Bosch, B., Férnandez-Villullas, G., Antonell, A., Augé, J. M., Lomeña, F., Perissinotti, A., Bargalló, N., Sánchez-Valle, R., & Lladó, A. (2019). Clinical applicability of diagnostic biomarkers in early-onset cognitive impairment. European Journal of Neurology, 26(8), 1098–1104. https://doi.org/10.1111/ene.13945

 

    • Borrego-Écija, S., Antonell, A., Puig-Butillé, J. A., Pericot, I., Prat-Bravo, C., Abellan-Vidal, M. T., Mallada, J., Olives, J., Falgàs, N., Oliva, R., Lladó, A., & Sánchez-Valle, R. (2019). Novel P397S MAPT variant associated with late onset and slow progressive frontotemporal dementia. Annals of Clinical and Translational Neurology, 6(8), 1559–1565. https://doi.org/10.1002/acn3.50844

 

    • Lladó, A., Tort-Merino, A., Sánchez-Valle, R., Falgàs, N., Balasa, M., Bosch, B., Castellví, M., Olives, J., Antonell, A., & Hornberger, M. (2018). The hippocampal longitudinal axis-relevance for underlying tau and TDP-43 pathology. Neurobiology of Aging, 70, 1–9. https://doi.org/10.1016/j.neurobiolaging.2018.05.035

 

    • Sánchez-Valle, R., Heslegrave, A., Foiani, M. S., Bosch, B., Antonell, A., Balasa, M., Lladó, A., Zetterberg, H., & Fox, N. C. (2018). Serum neurofilament light levels correlate with severity measures and neurodegeneration markers in autosomal dominant Alzheimer’s disease. Alzheimer’s Research & Therapy, 10(1), 113. https://doi.org/10.1186/s13195-018-0439-y

 

    • Carmona-Iragui, M., Balasa, M., Benejam, B., Alcolea, D., Fernández, S., Videla, L., Sala, I., Sánchez-Saudinós, M. B., Morenas-Rodriguez, E., Ribosa-Nogué, R., Illán-Gala, I., Gonzalez-Ortiz, S., Clarimón, J., Schmitt, F., Powell, D. K., Bosch, B., Lladó, A., Rafii, M. S., Head, E., Molinuevo, J. L., … Fortea, J. (2017). Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal-dominant Alzheimer’s disease. Alzheimer’s & Dementia, 13(11), 1251–1260. https://doi.org/10.1016/j.jalz.2017.03.007

 

    • Borrego-Écija, S., Morgado, J., Palencia-Madrid, L., Grau-Rivera, O., Reñé, R., Hernández, I., Almenar, C., Balasa, M., Antonell, A., Molinuevo, J. L., Lladó, A., Martínez de Pancorbo, M., Gelpi, E., & Sánchez-Valle, R. (2017). Frontotemporal Dementia Caused by the P301L Mutation in the MAPT Gene: Clinicopathological Features of 13 Cases from the Same Geographical Origin in Barcelona, Spain. Dementia and Geriatric Cognitive Disorders, 44(3-4), 213–221. https://doi.org/10.1159/000480077

 

    • Grau-Rivera, O., Calvo, A., Bargalló, N., Monté, G. C., Nos, C., Lladó, A., Molinuevo, J. L., Gelpi, E., & Sánchez-Valle, R. (2017). Quantitative Magnetic Resonance Abnormalities in Creutzfeldt-Jakob Disease and Fatal Insomnia. Journal of Alzheimer’s Disease : JAD, 55(1), 431–443. https://doi.org/10.3233/JAD-160750

 

    • Antonell, A., Lladó, A., Sánchez-Valle, R., Sanfeliu, C., Casserras, T., Rami, L., Muñoz-García, C., Dangla-Valls, A., Balasa, M., Boya, P., Kalko, S. G., & Molinuevo, J. L. (2016). Altered Blood Gene Expression of Tumor-Related Genes (PRKCB, BECN1, and CDKN2A) in Alzheimer’s Disease. Molecular Neurobiology, 53(9), 5902–5911. https://doi.org/10.1007/s12035-015-9483-9

 

    • Balasa, M., Gelpi, E., Martín, I., Antonell, A., Rey, M. J., Grau-Rivera, O., Molinuevo, J. L., Sánchez-Valle, R., Lladó, A., & Catalan collaborative Study Group for FTLD (2015). Diagnostic accuracy of behavioral variant frontotemporal dementia consortium criteria (FTDC) in a clinicopathological cohort. Neuropathology and Applied Neurobiology, 41(7), 882–892. https://doi.org/10.1111/nan.12194

 

    • Sala-Llonch, R., Lladó, A., Fortea, J., Bosch, B., Antonell, A., Balasa, M., Bargalló, N., Bartrés-Faz, D., Molinuevo, J. L., & Sánchez-Valle, R. (2015). Evolving brain structural changes in PSEN1 mutation carriers. Neurobiology of Aging, 36(3), 1261–1270. https://doi.org/10.1016/j.neurobiolaging.2014.12.022