DEVELOPMENTAL NEUROBIOLOGY AND REGENERATION

Principal Investigators

Eduardo Soriano

Full Professor

Developmental genes and neural plasticity

Marta Pascual

Associate Professor

Septohippocampal networks in Alzheimer’s Disease

Research team

 

Ferran Burgaya

Associate Professor

 

Fausto Alexander Ulloa

Associate Professor

 

Jesus Mariano Ureña

Associate Professor

 

Yasmina Manso

Postdoctoral Researcher

 

Antoni Parcerisas

Postdoctoral Researcher

 

Lluis Pujadas

Postdoctoral Researcher

 

Oriol Ros

Postdoctoral Researcher

 

Tiziana Cortrufo

Lecturer

 

Eva Davila

Early Stage Researcher

 

Katherine Herreraa

Early Stage Researcher

 

Alba Ortega

Early Stage Researcher

 

Alba del Valle Vilchez

Early Stage Researcher

Research Interest

 

The aim of this programme is to understand how key developmental genes (eg, Reelin) play a fundamental role in neuronal plasticity processes in the adult brain, which is crucial for complex neural functions (e.g. learning and memory). The rationale is that adult plasticity (adult neurogenesis and synaptic plasticity) is reminiscent of developmental processes. Because dysregulation of adult neurogenesis and synaptic plasticity are implicated in neurological and psychiatric disorders, we aim also to understand how these genes contribute to the pathology of these diseases and whether modelling developmental genes in the adult brain ameliorate these neural disorders.

Technologies & Methods

 

  • Immunostaining and in situ hybridisation
  • Histology
  • Advanced microscopy and confocal
  • Estereotaxic surgery
  • Mouse behavioural analysis
  • Deep RNA and DNA sequencing
  • Live imaging techniques
  • Cell and slice cultures
  • In vivo and in vitro gene delivery techniques
  • Calcium imaging and manipulation
  • Biochemistry: western blot, ELISA, enzymatic phosphatase and kinase activities
  • General molecular biology techniques

Featured Projects

 

    • Ajut per incentivar i consolidar la recerca d’excel·lència ja existent a les universitats públiques de Catalunya. Programa
      ICREA Academia 2014. Fundació Institució Catalana de Recerca i
      Estudis Avançats. Eduardo Soriano

 

    • Enfermedades neurodegenerativas (CIBERNED). Instituto de Salud Carlos III. Ministerio de Ciencia e Innovación. CB06/05/0098. Eduardo Soriano

 

    • Nuevos enfoque para entender la patogénesis y la terapéutica de la Enfermedad de Alzheimer. Ministerio de Economía y Competitividad. SAF2016-76340-R. Eduardo Soriano

 

    • Papel de la proteina de matriz extracelular Reelina en plasticidad neural y en la enfermedad de Alzheimer. MCINN. PID2019-106764RB-C21. Eduardo Soriano i Lluis Pujada

 

    • Regulación de la respuesta microglial y eliminación de Aβ por Reelina en la enfermedad de Alzheimer. CIBERNED, ISCIII. Eduardo Soriano

Featured Publications

 

    • Navas-Pérez, E., Vicente-García, C., Mirra, S., Burguera, D., Fernàndez-Castillo, N., Ferrán, J. L., López-Mayorga, M., Alaiz-Noya, M., Suárez-Pereira, I., Antón-Galindo, E., Ulloa, F., Herrera-Úbeda, C., Cuscó, P., Falcón-Moya, R., Rodríguez-Moreno, A., D’Aniello, S., Cormand, B., Marfany, G., Soriano, E., … Garcia-Fernàndez, J. (2020). Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions. Genome Biology, 21(1), 267. https://doi.org/10.1186/s13059-020-02172-3

 

    • Rossi, D., Gruart, A., Contreras-Murillo, G., Muhaisen, A., Ávila, J., Delgado-García, J. M., Pujadas, L., & Soriano, E. (2020). Reelin reverts biochemical, physiological and cognitive alterations in mouse models of Tauopathy. Progress in Neurobiology, 186, 101743. https://doi.org/10.1016/j.pneurobio.2019.101743

 

    • Ros, O., Barrecheguren, P. J., Cotrufo, T., Schaettin, M., Roselló-Busquets, C., Vílchez-Acosta, A., Hernaiz-Llorens, M., Martínez-Marmol, R., Ulloa, F., Stoeckli, E. T., Araújo, S. J., & Soriano, E. (2018). A conserved role for Syntaxin-1 in pre- and post-commissural midline axonal guidance in fly, chick, and mouse. PLOS Genetics, 14(6), e1007432. https://doi.org/10.1371/journal.pgen.1007432

 

    • Labouesse, M. A., Lassalle, O., Richetto, J., Iafrati, J., Weber-Stadlbauer, U., Notter, T., Gschwind, T., Pujadas, L., Soriano, E., Reichelt, A. C., Labouesse, C., Langhans, W., Chavis, P., & Meyer, U. (2017). Hypervulnerability of the adolescent prefrontal cortex to nutritional stress via reelin deficiency. Molecular Psychiatry, 22(7), 961–971. https://doi.org/10.1038/mp.2016.193

 

    • Sánchez-Huertas, C., Freixo, F., Viais, R., Lacasa, C., Soriano, E., & Lüders, J. (2016). Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity. Nature Communications, 7(1), 12187. https://doi.org/10.1038/ncomms12187

 

    • Ros, O., Cotrufo, T., Martínez-Mármol, R., & Soriano, E. (2015). Regulation of Patterned Dynamics of Local Exocytosis in Growth Cones by Netrin-1. Journal of Neuroscience, 35(13), 5156 LP – 5170. https://doi.org/10.1523/JNEUROSCI.0124-14.2015

 

    • Pujadas, L., Rossi, D., Andrés, R., Teixeira, C. M., Serra-Vidal, B., Parcerisas, A., Maldonado, R., Giralt, E., Carulla, N., & Soriano, E. (2014). Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer’s disease. Nature Communications, 5(1), 3443. https://doi.org/10.1038/ncomms4443