Research Interest

The aim of this programme is to understand how key developmental genes (eg, Reelin) play a fundamental role in neuronal plasticity processes in the adult brain, which is crucial for complex neural functions (e.g. learning and memory). The rationale is that adult plasticity (adult neurogenesis and synaptic plasticity) is reminiscent of developmental processes. Because dysregulation of adult neurogenesis and synaptic plasticity are implicated in neurological and psychiatric disorders, we aim also to understand how these genes contribute to the pathology of these diseases and whether modelling developmental genes in the adult brain ameliorate these neural disorders.

Technologies & Methods

• Immunostaining and in situ hybridisation
• Histology
• Advanced microscopy and confocal
• Estereotaxic surgery
• Mouse behavioural analysis
• Deep RNA and DNA sequencing
• Live imaging techniques
• Cell and slice cultures
• In vivo and in vitro gene delivery techniques
• Calcium imaging and manipulation
• Biochemistry: western blot, ELISA, enzymatic phosphatase and kinase activities
• General molecular biology techniques

Active Projects

• • Enfermedades neurodegenerativas. Ministerio de Sanidad y
    Consumo. CB06/05/0098. Eduardo Soriano.

• • Integrative Platforms for Axon guidance. Agència de Gestió d’Ajuts Universitaris i de Recerca. 2019 BP 00250. Eduardo Soriano

• • Neurobiologia del Desenvolupament i la Regeneració Neuronal. Agència de Gestió d’Ajuts Universitaris i de Recerca. 2017SGR1280. Eduardo Soriano

• • Papel de la proteina de matriz extracelular Reelina en plasticidad neural y en la enfermedad de Alzheimer. Ministerio de Ciencia, Innovación y Universidades. PID2019-106764RB-C21. Eduardo Soriano.

Featured Publications

• • Navas-Pérez, E., Vicente-García, C., Mirra, S., Burguera, D., Fernàndez-Castillo, N., Ferrán, J. L., López-Mayorga, M., Alaiz-Noya, M., Suárez-Pereira, I., Antón-Galindo, E., Ulloa, F., Herrera-Úbeda, C., Cuscó, P., Falcón-Moya, R., Rodríguez-Moreno, A., D’Aniello, S., Cormand, B., Marfany, G., Soriano, E., … Garcia-Fernàndez, J. (2020). Characterization of an eutherian gene cluster generated after transposon domestication identifies Bex3 as relevant for advanced neurological functions. Genome Biology, 21(1), 267. https://doi.org/10.1186/s13059-020-02172-3

• • Rossi, D., Gruart, A., Contreras-Murillo, G., Muhaisen, A., Ávila, J., Delgado-García, J. M., Pujadas, L., & Soriano, E. (2020). Reelin reverts biochemical, physiological and cognitive alterations in mouse models of Tauopathy. Progress in Neurobiology, 186, 101743. https://doi.org/10.1016/j.pneurobio.2019.101743

• • Ros, O., Barrecheguren, P. J., Cotrufo, T., Schaettin, M., Roselló-Busquets, C., Vílchez-Acosta, A., Hernaiz-Llorens, M., Martínez-Marmol, R., Ulloa, F., Stoeckli, E. T., Araújo, S. J., & Soriano, E. (2018). A conserved role for Syntaxin-1 in pre- and post-commissural midline axonal guidance in fly, chick, and mouse. PLOS Genetics, 14(6), e1007432. https://doi.org/10.1371/journal.pgen.1007432

• • Labouesse, M. A., Lassalle, O., Richetto, J., Iafrati, J., Weber-Stadlbauer, U., Notter, T., Gschwind, T., Pujadas, L., Soriano, E., Reichelt, A. C., Labouesse, C., Langhans, W., Chavis, P., & Meyer, U. (2017). Hypervulnerability of the adolescent prefrontal cortex to nutritional stress via reelin deficiency. Molecular Psychiatry, 22(7), 961–971. https://doi.org/10.1038/mp.2016.193

• • Sánchez-Huertas, C., Freixo, F., Viais, R., Lacasa, C., Soriano, E., & Lüders, J. (2016). Non-centrosomal nucleation mediated by augmin organizes microtubules in post-mitotic neurons and controls axonal microtubule polarity. Nature Communications, 7(1), 12187. https://doi.org/10.1038/ncomms12187

• • Ros, O., Cotrufo, T., Martínez-Mármol, R., & Soriano, E. (2015). Regulation of Patterned Dynamics of Local Exocytosis in Growth Cones by Netrin-1. Journal of Neuroscience, 35(13), 5156 LP – 5170. https://doi.org/10.1523/JNEUROSCI.0124-14.2015

• • Pujadas, L., Rossi, D., Andrés, R., Teixeira, C. M., Serra-Vidal, B., Parcerisas, A., Maldonado, R., Giralt, E., Carulla, N., & Soriano, E. (2014). Reelin delays amyloid-beta fibril formation and rescues cognitive deficits in a model of Alzheimer’s disease. Nature Communications, 5(1), 3443. https://doi.org/10.1038/ncomms4443