ORCID Research Profile
JOSÉ ANTONIO DEL RÍO FERNÁNDEZ
Position: Group Leader at the
Institute for Bioengineering of Catalonia
Prof. in Cell Biology
Research team
Rosalina Gavín Marín
Associate Professor
rgavin (at) ub.edu
Vanesa Gil Fernandez
Postdoctoral researcher
vagilfer (at) ub.edu
Ana López Mengual
Early stage researcher
alopezme22 (at) alumnes.ub.edu
Laia Lidón Gil
Early stage researcher
llidongi8 (at) alumnes.ub.edu
Andreu Matamoros i Angles
Early stage researcher
amatamoros (at) ub.edu
Agata Mata Rodriguez
Early stage researcher
Laura Urrea Zazurca
Early stage researcher
Miriam Segura Feliu
Administrative and technical staff
Contact details
Prof. José Antonio del Río Fernández
Department of Cell Biology, Physiology and Immunology
Faculty of Biology, Diagonal 643
08028 Barcelona (Spain)
934035923
jadelrio (at) ub.edu
www.ibecbarcelona.eu/es/research-groups/molecular-and-cellular-neurobiotechnology
Research Interests
The group is interested in understanding the processes of development, neuronal plasticity and neurodegeneration of the central nervous system (CNS). The main objective is to determine the biochemical function of genes overexpressed during development and neurodegeneration and their particular roles in the CNS. Thus current experiments of the group focused in i) the role of angiogenic factors during cortical development; ii) to develop new approaches to enhance axon regeneration, iii) new biomarkers and detection methods for Alzheimer´s and iv) characterization of the neurodegenerative process in prionopathies.
Current Research Lines
- Functions of the celular prion protein in the CNS
- Angiogenic factors and neural development
- Epigenetic factors and axon regeneration
- Cell therapy for spinal cord research
- New biomarkers and detection method for Alzheimer´s disease
Technologies / methods
- Microfluidic devices and lab on a chip platforms. Please see: Tong Z, Segura-Feliu M, Seira O, Homs-Corbera A, Del Río JA*, Samitier J* (2015) A microfluidic neuronal platform for neuron axotomy and controlled regenerative studies. RSC Advances. 90(20): 73457-73466 | Tong Z, Seira O, Casas C, Reginensi D, Homs-Corbera A, Samitier J*, Del Río JA* (2014) Engineering a functional neuro-muscular junction model in a chip. RSC Advances 4(97): 54788-54797. (for details)
- In vitro explant and organotypic cultures. Please see: Gil V, Del Rio JA (2012) Analysis of axonal growth and cell migration in 3D hydrogel cultures of embryonic mouse CNS tissue. Nature protocols 7 (2):268-280. | Del Rio JA, Soriano E (2010) Regenerating cortical connections in a dish: the entorhino-hippocampal organotypic slice co-culture as tool for pharmacological screening of molecules promoting axon regeneration. Nature protocols 5 (2):217-226. (for details)
- Molecular and celular biology laboratory. Please see: Llorens F, Banez-Coronel M, Pantano L, Del Rio JA, Ferrer I, Estivill X, Marti E (2013) A highly expressed miR-101 isomiR is a functional silencing small RNA. BMC genomics 14:104. | Llorens F, Ferrer I, Del Rio JA* (2014) Gene expression resulting from PrPC ablation and PrPC overexpression in murine and cellular models. Molecular Neurobiology 49 (1):413-423. (for details)
Highlighted publications
· Carulla P, Llorens F, Matamoros-Angles A, Aguilar-Calvo P, Espinosa JC, Gavin R, Ferrer I, Legname G, Torres JM, Del Rio JA (2015) Involvement of PrP(C) in kainate-induced excitotoxicity in several mouse strains. Scientific reports 5:11971.
· Bribian A, Nocentini S, Llorens F, Gil V, Mire E, Reginensi D, Yoshida Y, Mann F, Del Rio JA (2014) Sema3E/PlexinD1 regulates the migration of hem-derived Cajal-Retzius cells in developing cerebral cortex. Nature communications 5:4265.
· Reginensi D, Carulla P, Nocentini S, Seira O, Serra-Picamal X, Torres-Espin A, Matamoros-Angles A, Gavin R, Moreno-Flores MT, Wandosell F, Samitier J, Trepat X, Navarro X, Del Rio JA (2015) Increased migration of olfactory ensheathing cells secreting the Nogo receptor ectodomain over inhibitory substrates and lesioned spinal cord. Cellular and molecular life sciences: CMLS 72 (14):2719-2737.
· Gil V, Del Rio JA (2012) Analysis of axonal growth and cell migration in 3D hydrogel cultures of embryonic mouse CNS tissue. Nature protocols 7 (2):268-280.
· Llorens F, Gil V, Del Rio JA (2011) Emerging functions of myelin-associated proteins during development, neuronal plasticity, and neurodegeneration. FASEB journal 25 (2):463-475.