Group of Neurochemistry

ORCID Research Profile

Manuel J Rodríguez

Position: Associate Professor

Research team


Esther García García

Early stage researcher


Nerea Chaparro

Early stage researcher


Contact details

Dr. Manuel J Rodríguez Allué

Department of Biomedicine

School of Medicine and Health Sciences, Casanova 143

08036 Barcelona (Spain)

Tel: 934024525

marodriguez (at)

Research Interests


We conduct research to better understand the cellular and molecular mechanisms underlying neurodegenerative processes in humans. We have experience in the research of the physiopathological processes present in several neurological disorders such as stroke, multiple sclerosis, amyotrophic lateral sclerosis and Huntington’s disease. Our main objective is to gain knowledge of the mechanisms regulating neuroinflammation associated with such neurological disorders.

Current Research Lines


  • Role of microglia in the synaptic dysfunction processes present in Huntington’s disease.
  • Study of the VPS13a protein function in basal ganglia neurons and its relevance in movement disorders.


Technologies / methods

Mouse neuronal and glial cultures, primary cultures and cell lines, neuronal cultures, cellular biology, murine models, postmortem human brain samples use. Models for HD, immunohistochemistry, confocal microscopy, molecular biology, multi-electrode array.

Highlighted publications


·Vidal-Taboada JM, Pugliese M, Salvadó M, Gámez J, Mahy N, Rodríguez MJ. (2018) KATP channel expression and genetic polymorphisms associated with progression and survival in amyotrophic lateral sclerosis. Mol Neurobiol 55(10):7962-7972


·Rodriguez MJ, Mahy N. (2016) Neuron-microglia interactions in motor neuron degeneration. The inflammatory hypothesis in amyotrophic lateral sclerosis revisited. Curr Med Chem 23:4y.753-4772.


·Espinosa-Parrilla JF, Martínez-Moreno M, Gasull X, Mahy N, and Rodríguez MJ. (2015) The L-type voltage-gated calcium channel modulates microglial pro-inflammatory activity. Mol Cell Neurosci 64:104-115.


·Ortega FJ, Vukovic J, Rodríguez MJ, and Bartlett PF (2014) Blockade of microglial KATP-channel abrogates suppression of inflammatory-mediated inhibition of neural precursor cells. Glia 62:247-258.


·Ortega FJ, Jolkkonen J, Mahy N, and Rodríguez MJ (2013) Glibenclamide enhances neurogenesis and improves long-term functional recovery after transient focal cerebral ischemia. J Cereb Blood Flow Met 33:356-364.