NEUROPATHOLOGY

Principal Investigators

ISIDRO FERRER

Full Professor

Research team

 

Pol Andres-Benito

Postdoctoral Researcher

 

Marta Barrachina

Postdoctoral Researcher

Research Interest

 

Study of new alterations in metabolic pathways, and of clusters and hubs in the aging nervous system and at early stages of neurodegenerative diseases including Alzheimer’s disease (AD), Parkinson’s disease (PD), Dementia with Lewy Bodies, tauopathies, other frontotemporal lobar degenerations, prion diseases and amyotrophic lateral sclerosis; Studies human post-mortem brain samples from our brain bank and other centers belonging to the European Brain Bank Network Consortium; translation of the results to transgenic murine models and newly generated double-transgenic animals to test possible treatments; and assessment of possible CSF biomarkers mainly based on metabolomes. Our main goal has been the identification of new pathways, networks, hubs and clusters which are modified with age and altered at the initial stages of common neurodegenerative diseases in order to recognize putative targets and treatments for therapeutic prevention.

Technologies & Methods

 

  • Abnormal protein aggregate analysis
  • Molecular neuropathology
  • Combined use of genomics, transcriptomics, proteomics, redox proteomics, metabolomics, lipidomics and bioinformatic processing followed by validation by qRT-PCR, western blotting, ELISA, immunohistochemistry and enzymatic studies

Featured Projects

 

    • ARTAG (Aging-related tau astrogliopathy). Ministerio de Economía y Competitividad. PI17/00809. Isidro Ferrer

 

    • Contratos I-PFIS: doctorados IIS-empresa en ciencias y tecnologias de la salud.. Ministerio de Economia y Competitividad. IFI15/00035. Isidro Ferrer

 

    • Modulation of Tau seeding and pathology in tauopathies by BBB-nanocarriers, epitope selective vaccination and ectoPrP Tau receptor bodies (STOPTauPATHOL).. Fundació Caixa de Pensions ‘La Caixa’. HR18-00452. Isidro Ferrer

 

    • Projecte ELA.ELA Research Foundation. Isidro Ferrer

 

    • Red de Investigación Transfronteriza en Enfermedades Priónicas Humanas y Animales (REDPRION). European Union. EFA148/16 REDPRION. Isidro Ferrer

Featured Publications

 

    • Ferrer, I., Andrés-Benito, P., Sala-Jarque, J., Gil, V., & Del Rio, J. A. (2020). Capacity for Seeding and Spreading of Argyrophilic Grain Disease in a Wild-Type Murine Model; Comparisons With Primary Age-Related Tauopathy. Frontiers in molecular neuroscience, 13, 101. https://doi.org/10.3389/fnmol.2020.00101

 

    • Peña-Bautista, C., Torres-Cuevas, I., Baquero, M., Ferrer, I., García, L., Vento, M., & Cháfer-Pericás, C. (2020). Early neurotransmission impairment in non-invasive Alzheimer Disease detection. Scientific reports, 10(1), 16396. https://doi.org/10.1038/s41598-020-73362-z

 

    • Fourcade, S., Goicoechea, L., Parameswaran, J., Schlüter, A., Launay, N., Ruiz, M., Seyer, A., Colsch, B., Calingasan, N. Y., Ferrer, I., Beal, M. F., Sedel, F., & Pujol, A. (2020). High-dose biotin restores redox balance, energy and lipid homeostasis, and axonal health in a model of adrenoleukodystrophy. Brain pathology (Zurich, Switzerland), 30(5), 945–963. https://doi.org/10.1111/bpa.12869

 

    • Llorens, F., Villar-Piqué, A., Schmitz, M., Diaz-Lucena, D., Wohlhage, M., Hermann, P., Goebel, S., Schmidt, I., Glatzel, M., Hauw, J. J., Sikorska, B., Liberski, P. P., Riggert, J., Ferrer, I., & Zerr, I. (2020). Plasma total prion protein as a potential biomarker for neurodegenerative dementia: diagnostic accuracy in the spectrum of prion diseases. Neuropathology and applied neurobiology, 46(3), 240–254. https://doi.org/10.1111/nan.12573

 

    • Ferrer, I., Zelaya, M. V., Aguiló García, M., Carmona, M., López-González, I., Andrés-Benito, P., Lidón, L., Gavín, R., Garcia-Esparcia, P., & Del Rio, J. A. (2020). Relevance of host tau in tau seeding and spreading in tauopathies. Brain pathology (Zurich, Switzerland), 30(2), 298–318. https://doi.org/10.1111/bpa.12778

 

    • Younas, N., Zafar, S., Shafiq, M., Noor, A., Siegert, A., Arora, A. S., Galkin, A., Zafar, A., Schmitz, M., Stadelmann, C., Andreoletti, O., Ferrer, I., & Zerr, I. (2020). SFPQ and Tau: critical factors contributing to rapid progression of Alzheimer’s disease. Acta neuropathologica, 140(3), 317–339. https://doi.org/10.1007/s00401-020-02178-y

 

    • Villar-Piqué, A., Schmitz, M., Lachmann, I., Karch, A., Calero, O., Stehmann, C., Sarros, S., Ladogana, A., Poleggi, A., Santana, I., Ferrer, I., Mitrova, E., Žáková, D., Pocchiari, M., Baldeiras, I., Calero, M., Collins, S. J., Geschwind, M. D., Sánchez-Valle, R., Zerr, I., … Llorens, F. (2019). Cerebrospinal Fluid Total Prion Protein in the Spectrum of Prion Diseases. Molecular neurobiology, 56(4), 2811–2821. https://doi.org/10.1007/s12035-018-1251-1

 

    • Blennow, K., Diaz-Lucena, D., Zetterberg, H., Villar-Pique, A., Karch, A., Vidal, E., Hermann, P., Schmitz, M., Ferrer Abizanda, I., Zerr, I., & Llorens, F. (2019). CSF neurogranin as a neuronal damage marker in CJD: a comparative study with AD. Journal of neurology, neurosurgery, and psychiatry, 90(8), 846–853. https://doi.org/10.1136/jnnp-2018-320155

 

    • Aso, E., Martinsson, I., Appelhans, D., Effenberg, C., Benseny-Cases, N., Cladera, J., Gouras, G., Ferrer, I., & Klementieva, O. (2019). Poly(propylene imine) dendrimers with histidine-maltose shell as novel type of nanoparticles for synapse and memory protection. Nanomedicine : nanotechnology, biology, and medicine, 17, 198–209. https://doi.org/10.1016/j.nano.2019.01.010

Knowledge transfer & Innovation

 

    • Mitochondrial markers of neurodegenerative diseases.. AVCRI247-E