Research line

Glutamatergic receptors in synaptic transmission.

• Characterization and identification of interacting proteins regulating AMPA receptor function.
• Studies of synaptic plasticity (long term potentiation and depression).
• Characterization of newly synthesized therapeutic compounds on NMDA receptors.
• Functional studies on glutamate receptor mutations related to intellectual disabilities.

Capacities

• Disease / disorder characterization: Electrophysiological characterization of glutamate ion channels dysfunction
• Assessment of new treatments: Ion channel blockers and positive allosteric modulators
• In vitro models: Cell lines, neuronal cultures, hippocampal slices
• Others: Electrophysiology in several recording configurations

Keywords: electrophysiology (patch-clamp), ionotropic glutamate receptors, hippocampal pyramidal neurons, long term plasticity, single channel conductance, auxiliary subunits.

Contact

Dr. David Soto del Cerro

davidsoto (at) ub.edu