Research line

Huntington´s disease: toward an understanding of pathological mechanisms involved in cognitive and psychiatric symptoms.


Identification of new pharmacological targets to ameliorate or prevent the most important clinical hallmarks in HD:  Motor, cognitive and emotional disturbances.



  • Disease / disorder characterization: Behaviour (motor, cognition, emotional)
  • Assessment of new treatments: In vivo and in vitro analysis of cell death, biochemical parameters, synaptic function, behaviour
  • In vitro models: Neuronal striatal cell lines
  • In vivo models: Huntington´s disease mouse models


Keywords: synaptic plasticity deficits, neuroprotection, long-term memory impairments, depression, p75/TrkB/BDNF, Cdk5.



Dr. Sílvia Ginés Padrós

silviagines (at)