Research line

Mechanisms of neuronal hyperexcitability and chronic pain.

• Pathophysiological mechanisms of pain in sensory neurons
• Electrophysiological techniques for ion channel analysis. Drug effects targeting ion channels
• Identification of new therapeutic targets for acute and chronic pain and itch
• Behavioural animal models of pain/itch
• Ion channels and membrane receptors in ocular tissues involved in glaucoma and ocular hypertension pathophysiology.

Capacities

• Disease / disorder characterization: Acute and chronic pain and itch
• Treatment discovery: New molecular targets involving ion channels
• Assessment of new treatments: Ion channel modulators/blockers/activators
• In vitro models: Cellular models, neuronal cultures
• In vivo models: Animal models of pain and itch. Ocular models of pathology

Keywords: ion channels, electrophysiological techniques, pain, itch, ocular hypertension, glaucoma, sensory neurons, behavioural models of pain.

Contact

Dr. Xavier Gasull Casanova

xgasull (at) ub.edu