Research line

Mechanisms of neuronal hyperexcitability and chronic pain.


  • Pathophysiological mechanisms of pain in sensory neurons
  • Electrophysiological techniques for ion channel analysis. Drug effects targeting ion channels
  • Identification of new therapeutic targets for acute and chronic pain and itch
  • Behavioural animal models of pain/itch
  • Ion channels and membrane receptors in ocular tissues involved in glaucoma and ocular hypertension pathophysiology.



  • Disease / disorder characterization: Acute and chronic pain and itch
  • Treatment discovery: New molecular targets involving ion channels
  • Assessment of new treatments: Ion channel modulators/blockers/activators
  • In vitro models: Cellular models, neuronal cultures
  • In vivo models: Animal models of pain and itch. Ocular models of pathology


Keywords: ion channels, electrophysiological techniques, pain, itch, ocular hypertension, glaucoma, sensory neurons, behavioural models of pain.



Dr. Xavier Gasull Casanova

xgasull (at)