Alzheimer’s disease and other cognitive disorders group

ORCID Research Profile


Position: MD, PhD


Research team

Albert Lladó



Mircea Balasa



Magda Castellví



Lorena Rami

R3A researcher


Anna Antonell



Beatriz Bosch

clinical trials coordinator


Guadalupe Fernández



Jaume Olives



Adrià Tort

PhD student


Sergi Borrego

MD (Rio Hortega, PhD student)


Oscar Ramos

MD (PFIS, PhD student)


Cristina Muñoz

lab technician


Mariona Ruiz-Peris

 biomedical engineer, PhD student

Contact details

Dr. Raquel Sanchez Del Valle Díaz

Servei de Neurologia

Hospital Clinic.

Universitat de Barcelona

Villarroel, 170 E8P4

08036 Barcelona


Ph: +34-932275785

Fax: +34-932275783


The Alzheimer’s and Other Cognitive Disorders Group is a clinical and translational team devoted to the diagnosis and intervention, research and education in the field of neurodegenerative cognitive disorders and dementia. In addition, the group collaborates with pharmaceutical companies in the study of new drugs for the treatment of patients with cognitive problems (pharmacological clinical trials).

Research Interest

  1.  Investigations on clinical, molecular and imaging biomarkers that characterize the preclinical/predementia phases of Alzheimer disease and other neurodegenerative cognitive disorders.
  2.  Investigation of biological pathways involved in the pathogenesis of neurodegenerative dementias.

Current main Research Line

  • The study of genetically determined dementias
  • Biomarkers and intervention in early-onset sporadic Alzheimer’s disease.
  • Healthy aging – Alzheimer’s disease continuum and innovative tools in cognitive testing for early diagnosis
  • Rare neurodegenerative dementias: I)Frontotemporal lobar degeneration (frontotemporal dementia and Primary Progressive Aphasia) .
  • Prion diseases and other rapidly progressive dementias (RPD).  (PI: Dr Raquel Sánchez-Valle)
  • Neuropathology of neurodegenerative diseases (in collaboration with the Neurological tissue Bank-Biobanc-IDIBAPS-Hospital Clínic).
  • Clinical trials in Alzheimer’s disease
  • Non-pharmacological interventions in cognitive disorders.


Neuropsychological testing for early cognitive changes.
Neuroimaging: structural and functional MRI.
Blood and CSF biochemical markers.
Genetic counseling and genetic testing.

Highlighted Publications

Sánchez-Valle R, Heslegrave A, Foiani MS, Bosch B, Antonell A, Balasa M, Lladó A, Zetterberg H, Fox NC. Serum neurofilament light levels correlate with severity measures and neurodegeneration markers in autosomal dominant Alzheimer’s disease. Alzheimers Res Ther. 2018 Nov 3;10(1):113.


Lladó A, Tort-Merino A, Sánchez-Valle R, Falgàs N, Balasa M, Bosch B,Castellví M, Olives J, Antonell A, Hornberger M. The hippocampal longitudinal axis-relevance for underlying tau and TDP-43 pathology. Neurobiol Aging. 2018 Oct;70:1-9. doi: 10.1016/j.neurobiolaging.2018.05.035. Epub 2018 Jun 1. PubMed PMID: 29935415.


Borrego-Écija S, Morgado J, Palencia-Madrid L, Grau-Rivera O, Reñé R,Hernández I, Almenar C, Balasa M, Antonell A, Molinuevo JL, Lladó A, Martínez de Pancorbo M, Gelpi E, Sánchez-Valle R. Frontotemporal Dementia Caused by the P301L Mutation in the MAPT Gene: Clinicopathological Features of 13 Cases from the Same Geographical Origin in Barcelona, Spain. Dement Geriatr Cogn Disord.2017;44(3-4):213-221.


Carmona-Iragui M, Balasa M, Benejam B, Alcolea D, Fernández S, Videla L, Sala I, Sánchez-Saudinós MB, Morenas-Rodriguez E, Ribosa-Nogué R, Illán-Gala I, Gonzalez-Ortiz S, Clarimón J, Schmitt F, Powell DK, Bosch B, Lladó A, Rafii MS, Head E, Molinuevo JL, Blesa R, Videla S, Lleó A, Sánchez-Valle R*, Fortea J*.Cerebral amyloid angiopathy in Down syndrome and sporadic and autosomal-dominant Alzheimer’s disease. Alzheimers Dement. 2017 Nov;13(11):1251-1260.


Grau-Rivera O, Calvo A, Bargalló N, Monté GC, Nos C, Lladó A, Molinuevo JL,Gelpi E, Sánchez-Valle R. Quantitative Magnetic Resonance Abnormalities in Creutzfeldt-Jakob Disease and Fatal Insomnia. J Alzheimers Dis.2017;55(1):431-443. PubMed PMID: 27662320.


Antonell A, Lladó A, Sánchez-Valle R, Sanfeliu C, Casserras T, Rami L, Muñoz-García C, Dangla-Valls A, Balasa M, Boya P, Kalko SG, Molinuevo JL. Altered Blood Gene Expression of Tumor-Related Genes (PRKCB, BECN1, and CDKN2A) in Alzheimer’s Disease. Mol Neurobiol. 2016 Nov;53(9):5902-5911.


Sala-Llonch R, Lladó A, Fortea J, Bosch B, Antonell A, Balasa M, Bargalló N, Bartrés-Faz D, Molinuevo JL, Sánchez-Valle R. Evolving brain structural changes in PSEN1 mutation carriers. Neurobiol Aging. 2015 Mar;36(3):1261-70.


Balasa M, Gelpi E, Martín I, Antonell A, Rey MJ, Grau-Rivera O, Molinuevo JL,  Sánchez-Valle R*, Lladó A; Catalan collaborative Study Group for FTLD. Diagnostic accuracy of behavioral variant frontotemporal dementia consortium criteria (FTDC) in a clinicopathological cohort. Neuropathol Appl Neurobiol. 2015 Dec;41(7):882-92.