Position: Associate professor
(Professor titular d’Universitat)
Arcadio Gual Sala
agual (at) ub.edu
Nuria Comes Beltran
nuriacomes (at) ub.edu
Jonathan Peter Giblin
Senior postdoc (Ramón y Cajal research fellow)
jgiblin (at) ub.edu
Yaroslau Compta Hirnyj
ycompta (at) ub.edu
Aida Castellanos Esparraguera
Early stage researcher
aida.castellanos (at) ub.edu
Alba Andres Bilbe
Early stage researcher
albaandres (at) ub.edu
Montserrat Pau Ramon
Administrative and technical staff
montsepau (at) ub.edu
Dr. Xavier Gasull
Department of Biomedicine
School of Medicine, Casanova 143
08036 Barcelona (Spain)
xgasull (at) ub.edu
Within the field of neurophysiology, the group is interested in establishing the role of different ion channels implicated in shaping the excitability of sensory neurons of the dorsal root and trigeminal ganglia, and determining which alterations occur during injury, inflammatory and neuropathic pain states. We are especially interested on ocular pain after inflammation, injury or dry eye disease. On the other hand, in trabecular cells that regulate aqueous humor flow in the eye and intraocular pressure, we are exploring the role of neural mechanisms regulating intraocular pressure and ion K+ and Cl– channels that regulate contraction, shape and cell volume and how this is related to the physiopathology of glaucoma.
Furthermore, an additional line is that of studying disorders of the basal ganglia as Parkinson’s disease and other movement disorders, with focus on chemical correlates of neurodegeneration as alpha-synuclein, amyloid- and tau in both biofluids (as blood and cerebrospinal fluid) and brain tissue.
· Kovács I, Luna C, Quirce S, Mizerska K, Callejo G, Riestra A, Fernández-Sánchez L, Meseguer VM, Cuenca N, Merayo-Lloves J, Acosta MC, Gasull X, Belmonte C, Gallar J. (2016) Abnormal activity of corneal cold thermoreceptors underlies the unpleasant sensations in dry eye disease. Pain. 157(2):399-417.
· Callejo G, Castellanos A, Castany M, Gual A, Luna C, Acosta MC, Gallar J, Giblin JP, Gasull X. (2015) Acid-sensing ion channels detect moderate acidifications to induce ocular pain. Pain. 156(3):483-95.
· Delaunay A*, Gasull X*, Salinas M, Noël J, Friend V, Lingueglia E, Deval E. (2012) Human ASIC3 channel dynamically adapts its activity to sense the extracellular pH in both acidic and alkaline directions. Proc Natl Acad Sci USA. 109(32):13124-9.
· Soto D, Comes N, Ferrer E, Morales M, Escalada A, Palés J, Solsona C, Gual A, Gasull X. (2004) Modulation of aqueous humor outflow by ionic mechanisms involved in trabecular meshwork cell volume regulation. Invest Ophthalmol Vis Sci. 45(10):3650-61.
· Compta Y, Parkkinen L, O’Sullivan SS, Vandrovcova J, Holton JL, Collins C, Lashley T, Kallis C, Williams DR, de Silva R, Lees AJ, Revesz T. (2011) Lewy- and Alzheimer-type pathologies in Parkinson’s disease dementia: which is more important? Brain. 134(Pt 5):1493-505.