Position: Associate Professor
Dr. Soledad Alcántara Horrillo
Department of Pathology and Experimental Therapeutics
Faculty of Medicine, Feixa LLarga s/n
08907 L’Hospitalet de Llobregat (Spain)
salcantara (at) ub.edu
During nervous system development, genetic and environmental programs interplay to allow the sequential generation of neurons and glia and the initial establishment of the neural circuitry. At the end of this period, molecular sensors of electric activity (like BDNF) modulate neuronal and glial maturation, survival and the final wiring of the system. Effective regeneration after brain damage may require the reactivation of neurogenic neurovascular niches and the mechanisms of development required to replace the damage tissue.
The Neural Development group is focused in three main aspects of CNS development:
· Alvarez Z, Hyroššová P, Perales JC, Alcántara S. (2016) Neuronal Progenitor Maintenance Requires Lactate Metabolism and PEPCK-M-Directed Cataplerosis. Cerebral Cortex, 26:1046-58. Epub 2014 Dec 1.
· Alvarez Z, Castano O, Castells AA, Mateos-Timoneda MA, Planell JA, Engel E, Alcantara, S (2014) Neurogenesis and vascularization of the damaged brain using a lactate-releasing biomimetic scaffold. Biomaterials, 35:4769-4781.
· Alvarez, Z.; Mateos-Timoneda M.A.; Hiroššová, P.; Castaño O.; Planell, J.A.; Perales, J.C.; Engel, E.; Alcántara, S. (2013) The effect of the composition of PLA films and lactate release on glial and neuronal maturation and the maintenance of the neuronal progenitor niche. Biomaterials, 34:2221-2233.
· Mattotti, M.; Alvarez, Z.; Ortega, J.A.; Planell, J.A.; Engel, E.; Alcántara, S. (2012) Inducing functional radial glia-like progenitors from cortical astrocyte cultures using micropatterned PMMA. Biomaterials, 33:1759-1770.
· Ortega JA, and Alcántara S (2010): BDNF/MAPK/ERK-induced BMP7 expression in the developing cerebral cortex induces premature radial glia differentiation and impairs neuronal migration. Cerebral Cortex, 20:2132-2144.