Developmental Neurobiology and Regeneration

Pathophysiology of Nervous System Diseases

The aim of this programme is to understand how key developmental genes (eg, Reelin) play a fundamental role in neuronal plasticity processes in the adult brain, which is crucial for complex neural functions (e.g. learning and memory). The rationale is that adult plasticity (adult neurogenesis and synaptic plasticity) is reminiscent of developmental processes. Because dysregulation of adult neurogenesis and synaptic plasticity are implicated in neurological and psychiatric disorders, we aim also to understand how these genes contribute to the pathology of these diseases and whether modelling developmental genes in the adult brain ameliorate these neural disorders.

Principal Investigators

Eduardo Soriano

Full Professor

Yasmina Manso

Lecturer

Technologies & Methods

  • Immunostaining and in situ hybridisation
  • Histology
  • Advanced microscopy and confocal
  • Estereotaxic surgery
  • Mouse behavioural analysis
  • Deep RNA and DNA sequencing
  • Live imaging techniques
  • Cell and slice cultures
  • In vivo and in vitro gene delivery techniques
  • Calcium imaging and manipulation
  • Biochemistry: western blot, ELISA, enzymatic phosphatase and kinase activities
  • General molecular biology techniques

Research Team

Ferran Burgaya

Associate Professor

Antoni Parcerisas

Postdoctoral Researcher

Fausto Alexander Ulloa

Associate Professor

Marta Pascual

Associate Professor

Jesus Mariano Ureña

Associate Professor

Lluis Pujadas

Postdoctoral Researcher

Tiziana Cortrufo

Lecturer

Katherine Herrera

Early Stage Researcher

Alba Eliasi Tersa

Early Stage Researcher

Edgar Silk

Technician

Maria Ángeles Llanos

Early Stage Researcher

Selected publications

Martínez-Mármol, R., Muhaisen, A., Cotrufo, T., Roselló-Busquets, C., Ros, O., Hernaiz-Llorens, M., Pérez-Branguli, F., Andrés, R. M., Parcerisas, A., Pascual, M., Ulloa, F., & Soriano, E. (2023a). Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion. Frontiers in Molecular Neuroscience, 16. https://doi.org/10.3389/fnmol.2023.1253954

Olloquequi, J., Ettcheto, M., Cano, A., Fortuna, A., Bicker, J., Sánchez-Lopez, E., Paz, C., Ureña, J., Verdaguer, E., Auladell, C., & Camins, A. (2023). Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment. International Journal of Molecular Sciences, 24(18), 14177. https://doi.org/10.3390/ijms241814177

Ortega-Gascó, A., Parcerisas, A., Hino, K., Herranz-Pérez, V., Ulloa, F., Elias-Tersa, A., Bosch, M., García-Verdugo, J. M., Simó, S., Pujadas, L., & Soriano, E. (2023). Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2). Cerebral Cortex, 33(21), 10931–10948. https://doi.org/10.1093/cercor/bhad340