Developmental Neurobiology and Regeneration
The aim of this programme is to understand how key developmental genes (eg, Reelin) play a fundamental role in neuronal plasticity processes in the adult brain, which is crucial for complex neural functions (e.g. learning and memory). The rationale is that adult plasticity (adult neurogenesis and synaptic plasticity) is reminiscent of developmental processes. Because dysregulation of adult neurogenesis and synaptic plasticity are implicated in neurological and psychiatric disorders, we aim also to understand how these genes contribute to the pathology of these diseases and whether modelling developmental genes in the adult brain ameliorate these neural disorders.
Principal Investigators
Eduardo Soriano
Full Professor
Yasmina Manso
Lecturer
Technologies & Methods
- Immunostaining and in situ hybridisation
- Histology
- Advanced microscopy and confocal
- Estereotaxic surgery
- Mouse behavioural analysis
- Deep RNA and DNA sequencing
- Live imaging techniques
- Cell and slice cultures
- In vivo and in vitro gene delivery techniques
- Calcium imaging and manipulation
- Biochemistry: western blot, ELISA, enzymatic phosphatase and kinase activities
- General molecular biology techniques
Research Team
Ferran Burgaya
Associate Professor
Antoni Parcerisas
Postdoctoral Researcher
Fausto Alexander Ulloa
Associate Professor
Marta Pascual
Associate Professor
Jesus Mariano Ureña
Associate Professor
Lluis Pujadas
Postdoctoral Researcher
Tiziana Cortrufo
Lecturer
Katherine Herrera
Early Stage Researcher
Alba Eliasi Tersa
Early Stage Researcher
Edgar Silk
Technician
Maria Ángeles Llanos
Early Stage Researcher
Active Projects
Enfermedades neurodegenerativas
Ministerio de Sanidad y Consumo. CB06/05/0098. Eduardo Soriano.
Selected publications
Martínez-Mármol, R., Muhaisen, A., Cotrufo, T., Roselló-Busquets, C., Ros, O., Hernaiz-Llorens, M., Pérez-Branguli, F., Andrés, R. M., Parcerisas, A., Pascual, M., Ulloa, F., & Soriano, E. (2023a). Syntaxin-1 is necessary for UNC5A-C/Netrin-1-dependent macropinocytosis and chemorepulsion. Frontiers in Molecular Neuroscience, 16. https://doi.org/10.3389/fnmol.2023.1253954
Olloquequi, J., Ettcheto, M., Cano, A., Fortuna, A., Bicker, J., Sánchez-Lopez, E., Paz, C., Ureña, J., Verdaguer, E., Auladell, C., & Camins, A. (2023). Licochalcone A: A Potential Multitarget Drug for Alzheimer’s Disease Treatment. International Journal of Molecular Sciences, 24(18), 14177. https://doi.org/10.3390/ijms241814177
Ortega-Gascó, A., Parcerisas, A., Hino, K., Herranz-Pérez, V., Ulloa, F., Elias-Tersa, A., Bosch, M., García-Verdugo, J. M., Simó, S., Pujadas, L., & Soriano, E. (2023). Regulation of young-adult neurogenesis and neuronal differentiation by neural cell adhesion molecule 2 (NCAM2). Cerebral Cortex, 33(21), 10931–10948. https://doi.org/10.1093/cercor/bhad340