Research Interest

The aim of this programme is to understand how key developmental genes (eg, Reelin) play a fundamental role in neuronal plasticity processes in the adult brain, which is crucial for complex neural functions (e.g. learning and memory). The rationale is that adult plasticity (adult neurogenesis and synaptic plasticity) is reminiscent of developmental processes. Because dysregulation of adult neurogenesis and synaptic plasticity are implicated in neurological and psychiatric disorders, we aim also to understand how these genes contribute to the pathology of these diseases and whether modelling developmental genes in the adult brain ameliorate these neural disorders.

Technologies & Methods

• Immunostaining and in situ hybridisation
• Histology
• Advanced microscopy and confocal
• Estereotaxic surgery
• Mouse behavioural analysis
• Deep RNA and DNA sequencing
• Live imaging techniques
• Cell and slice cultures
• In vivo and in vitro gene delivery techniques
• Calcium imaging and manipulation
• Biochemistry: western blot, ELISA, enzymatic phosphatase and kinase activities
• General molecular biology techniques

Active Projects

Enfermedades neurodegenerativas. Ministerio de Sanidad y Consumo. CB06/05/0098. Eduardo Soriano.

Featured Publications

• • Dávila-Bouziguet, E., Casòliba-Melich, A., Targa-Fabra, G., GaleraLópez, L., Ozaita, A., Maldonado, R., Ávila, J., Delgado-García, J. M., Gruart, A., Soriano, E., & Pascual, M. (2022). Functional protection in J20/VLW mice: a model of non-demented with Alzheimer’s disease neuropathology. Brain, 145(2), 729–743. https:www//doi. org/10.1093/brain/awab319

• • Gavaldà-Navarro, A., Mirra, S., Manso, Y., Sánchez-Infantes, D., Giralt, M., Soriano, E., & Villarroya, F. (2022c). The armadillo-repeat containing X-linked protein 3, ARMCX3, is a negative regulator of the browning of adipose tissue associated with obesity. International Journal of Obesity, 46(9), 1652–1661. https://doi. org/10.1038/s41366-022-01169-1

• • Lobon, I., Solís-Moruno, M., Juan, D., Muhaisen, A., Abascal, F., Esteller-Cucala, P., García-Pérez, R., Martí, M. J., Tolosa, E., Ávila, J., Rahbari, R., Marques-Bonet, T., Casals, F., & Soriano, E. (2022). Somatic Mutations Detected in Parkinson Disease Could Affect Genes With a Role in Synaptic and Neuronal Processes. Frontiers in Aging, 3. https://doi.org/10.3389/fragi.2022.851039

• • Ortega-Gascó, A., Parcerisas, A., Hino, K., Herranz-Pérez, V., Ulloa, F., Elias-Tersa, A., Bosch, M., García-Verdugo, J. M., Simó, S., Pujadas, L., & Soriano, E. (n.d.). Regulation of adult neurogenesis and neuronal differentiation by Neural Cell Adhesion Molecule 2 (NCAM2). https://doi.org/10.1101/2022.02.03.478938

• • Vílchez-Acosta, A., Manso, Y., Cárdenas, A., Elias-Tersa, A., Martínez-Losa, M., Pascual, M., Álvarez-Dolado, M., Nairn, A. C., Borrell, V., & Soriano, E. (2022). Specific contribution of Reelin expressed by Cajal–Retzius cells or GABAergic interneurons to cortical lamination. Proceedings of the National Academy of Sciences, 119(37). https://doi.org/10.1073/pnas.2120079119