Bipolar and Depressive Disorders
The bipolar and depressive disorders programme, characterised by a multidisciplinary approach, investigates the neurobiological and anatomofunctional mechanisms involved in the development of the disease (genetics, neuromodulators, hormone factors and neuroimaging) and its relapses, the clinical course and neuropsychological consequences, the efficacy of drug treatments and novel therapies, and psychological interventions for the early detection and relapse prevention, the therapeutic adherence enhancement; and the improvement of the effectiveness of therapeutic strategies for affective disorders. Its strategic objectives are to investigate the causes and mechanisms involved in the etiopathogenesis of bipolar and unipolar disorders and their treatment under the new paradigm of Precision Psychiatry.
Technologies & Methods
- Psychiatric assessment and treatment
- Clinical trial design and methodology
- Development, evaluation, and implementation of digital technologies in the field of mental health
- Precision Psychiatry
Research Team
Antoni Benabarre
Lecturer
Iria Grande
Lecturer
Anabel Martinez-Aran
Lecturer
Marina Garriga
Postdoctoral Researcher
Diego Hidalgo
Postdoctoral Researcher
Ester Jimenez
Postdoctoral Researcher
Andrea Murru
Postdoctoral Researcher
Isabella Pacchiarotti
Postdoctoral Researcher
Carla Torrent
Postdoctoral Researcher
Marc Valenti
Postdoctoral Researcher
Gerard Anmella
Postdoctoral Researcher
Derek Clougher
Early Stage Researcher
Giovanna Fico
Postdoctoral Researcher
Anna Gimenez
Early Stage Researcher
Maria Sagué
Early Stage Researcher
Laura Montejo
Postdoctoral Researcher
Jose Sanchez-Moreno
Postdoctoral Researcher
Brisa Sole
Postdoctoral Researcher
Maria Serra-Navarro
Early Stage Researcher
Maria Florencia Forte
Early Stage Researcher
Natalia Roberto Herrero
Early Stage Researcher
Michele De Prisco
Early Stage Researcher
Vincenzo Oliva
Early Stage Researcher
Natalia E Fares-Otero
Early Stage Researcher
Ariadna Mas-Musons
Early Stage Researcher
Marta Bort
Early Stage Researcher
Lidia Ilzarbe Simorte
Early Stage Researcher
Mariadelos Angeles Botí
Early Stage Researcher
Active Projects
Salud Mental (CIBERSAM)
Ministerio de Sanidad y Consumo. CB07/09/0004. Eduard Vieta.
A New Intervention for Implementation of Pharmacogenetics in Psychiatry
Unió Europea. 945151. Eduard Vieta.
Biomarcadores de neuroimagen de la reserva cognitiva en pacientes con un primer episodio psicótico/maniaco (NeuroBioCoRe)
Ministerio de Ciencia, Innovación y Universidades. PI21/00787. Eduard Vieta.
Desxifrant els correlats clínics, neurobiològics i genètics delsprimers episodis de mania en el trastorn bipolar: projecte NOTION
Fundació La Marató de TV3. 202234. Eduard Vieta.
Contratos Juan Rodes
Ministerio de Sanidad y Consumo. JR18/00021. Eduard Vieta.
Psych-STRATA – A Stratified Treatment Algorithm in Psychiatry: A program on stratified pharmacogenomics in severe mental illness
Unió Europea. 101057454. Eduard Vieta.
Completed suicide as an extreme phenotype for understanding suicidal behavior: an integrative approach based on the interplay between genomics and epigenomics
Fundació La Marató de TV3. 202203-30. Antoni Benabarre.
Contratos Miguel Servet Tipo II 2019
Instituto de Salud Carlos III. CPII19/00009. Eduard Vieta.
Safety intervention for improving functioning in suicidal attempters
Fundació Clínic per a la Recerca Biomèdica. FCRB_PB1_2022. Iria Grande.
Enhancing Cognitive Function in Older-Age patients with Bipolar Disorder
Fundació Clínic per a la Recerca Biomèdica. FCRB_PB2_2022. Ana Isabel.
Brain and blood coexpression networks using DDR1 as a seed gene in bipolar disorder.Brain and blood coexpression networks using DDR1 as a seed gene in bipolar disorder. Identification of new biomarkers.
Fundació La Marató de TV3. 202235-33. Ana Isabel.
Descifrando la base genética y epigenética de la conducta suicida: desde los intentos de suicidio hasta el suicidio completo
Instituto de Salud Carlos III. PI22/01048. Antoni Benabarre.
Trastorns Bipolars i Depressius
Agència de Gestió d'Ajuts Universitaris i de Recerca (AGAUR). 2021 SGR 01358. Eduard Vieta.
NeurobiologiaTrastorns bipolars i depressius.
Fundació Clínic per a la Recerca Biomèdica. DN040734. Eduard Vieta.
Selected publications
Anmella, G., Sanabra, M., Primé-Tous, M., Segú, X., Cavero, M., Morilla, I., Grande, I., Ruiz, V., Mas, A., Martín-Villalba, I., Caballo, A., Esteva, J.-P., Rodríguez-Rey, A., Piazza, F., Valdesoiro, F. J., Rodriguez-Torrella, C., Espinosa, M., Virgili, G., Sorroche, C., … Hidalgo-Mazzei, D. (2023). Vickybot, a Chatbot for Anxiety-Depressive Symptoms and Work-Related Burnout in Primary Care and Health Care Professionals: Development, Feasibility, and Potential Effectiveness Studies. Journal of Medical Internet Research, 25, e43293. https://doi.org/10.2196/43293
Bioque, M., Rumià, J., Roldán, P., Hidalgo-Mazzei, D., Montejo, L., Benabarre, A., Gil-Badenes, J., Tercero, J., Parellada, E., & Vieta, E. (2023). Deep brain stimulation and digital monitoring for patients with treatment-resistant schizophrenia and bipolar disorder: A case series. Revista de Psiquiatría y Salud Mental. https://doi.org/10.1016/j.rpsm.2023.05.001
Crovetto, F., Nakaki, A., Arranz, A., Borras, R., Vellvé, K., Paules, C., Boutet, M. L., Castro-Barquero, S., Freitas, T., Casas, R., Martín-Asuero, A., Oller Guzmán, T., Morilla, I., Martínez-Àran, A., Camacho, A., Pasqual, M., Izquierdo Renau, M., Pozo, Ó. J., Gomez-Gomez, A., … Gratacós, E. (2023). Effect of a Mediterranean Diet or Mindfulness-Based Stress Reduction During Pregnancy on Child Neurodevelopment. JAMA Network Open, 6(8), e2330255. https://doi.org/10.1001/jamanetworkopen.2023.30255
Fares-Otero, N. E., Alameda, L., Pfaltz, M. C., Martinez-Aran, A., Schäfer, I., & Vieta, E. (2023). Examining associations, moderators and mediators between childhood maltreatment, social functioning, and social cognition in psychotic disorders: a systematic review and meta-analysis. Psychological Medicine, 53(13), 5909–5932. https://doi.org/10.1017/S0033291723001678
Fares‐Otero, N. E., De Prisco, M., Oliva, V., Radua, J., Halligan, S. L., Vieta, E., & Martinez‐Aran, A. (2023). Association between childhood maltreatment and social functioning in individuals with affective disorders: A systematic review and meta‐analysis. Acta Psychiatrica Scandinavica, 148(2), 142–164. https://doi.org/10.1111/acps.13557
Fico, G., Janiri, D., Pinna, M., Sagué-Vilavella, M., Gimenez Palomo, A., Oliva, V., De Prisco, M., Cortez, P. G., Anmella, G., Gonda, X., Sani, G., Tondo, L., Vieta, E., & Murru, A. (2023). Affective temperaments mediate aggressive dimensions in bipolar disorders: A cluster analysis from a large, cross-sectional, international study. Journal of Affective Disorders, 323, 327–335. https://doi.org/10.1016/j.jad.2022.11.084
Giménez‐Palomo, A., Gomes‐da‐Costa, S., Borràs, R., Pons‐Cabrera, M. T., Doncel‐Moriano, A., Arbelo, N., Leyes, P., Forga, M., Mateu‐Salat, M., Pereira‐Fernandes, P. M., Benabarre, A., Pacchiarotti, I., & Vieta, E. (2023). Effects of malnutrition on length of stay in patients hospitalized in an acute psychiatric ward. Acta Psychiatrica Scandinavica, 148(4), 316–326. https://doi.org/10.1111/acps.13598
Gomes-da-Costa, S., Solé, E., Williams, E., Giménez, A., Garriga, M., Pacchiarotti, I., Vázquez, M., Cavero, M., Blanch, J., Pérez, V., Palao, D., Vieta, E., & Verdolini, N. (2023). The impact of the Catalonia Suicide Risk Code (CSRC) in a tertiary hospital: Reduction in hospitalizations and emergency room visits for any reason but not for suicide attempt. Spanish Journal of Psychiatry and Mental Health, 16(2), 68–75. https://doi.org/10.1016/j.rpsm.2021.05.004
Khanra, S., Reddy, P., Giménez-Palomo, A., Park, C. H. J., Panizzutti, B., McCallum, M., Arumugham, S. S., Umesh, S., Debnath, M., Das, B., Venkatasubramanian, G., Ashton, M., Turner, A., Dean, O. M., Walder, K., Vieta, E., Yatham, L. N., Pacchiarotti, I., Reddy, Y. C. J., … Kim, J. H. (2023). Metabolic regulation to treat bipolar depression: mechanisms and targeting by trimetazidine. Molecular Psychiatry, 28(8), 3231–3242. https://doi.org/10.1038/s41380-023-02134-8
McWhinney, S. R., Abé, C., Alda, M., Benedetti, F., Bøen, E., del Mar Bonnin, C., Borgers, T., Brosch, K., Canales-Rodríguez, E. J., Cannon, D. M., Dannlowski, U., Diaz-Zuluaga, A. M., Dietze, L. M. F., Elvsåshagen, T., Eyler, L. T., Fullerton, J. M., Goikolea, J. M., Goltermann, J., Grotegerd, D., … Hajek, T. (2023). Mega-analysis of association between obesity and cortical morphology in bipolar disorders: ENIGMA study in 2832 participants. Psychological Medicine, 53(14), 6743–6753. https://doi.org/10.1017/S0033291723000223
Nakaki, A., Crovetto, F., Urru, A., Piella, G., Borras, R., Comte, V., Vellvé, K., Paules, C., Segalés, L., Dacal, M., Gomez, Y., Youssef, L., Casas, R., Castro-Barquero, S., Martín-Asuero, A., Oller Guzmán, T., Morilla, I., Martínez-Àran, A., Camacho, A., … Gratacós, E. (2023). Effects of Mediterranean diet or mindfulness-based stress reduction on fetal and neonatal brain development: a secondary analysis of a randomized clinical trial. American Journal of Obstetrics & Gynecology MFM, 5(12), 101188. https://doi.org/10.1016/j.ajogmf.2023.101188
Portillo-Van Diest, A., Vilagut, G., Alayo, I., Ferrer, M., Amigo, F., Amann, B. L., Aragón-Peña, A., Aragonès, E., Asúnsolo Del Barco, Á., Campos, M., Del Cura-González, I., Espuga, M., González-Pinto, A., Haro, J. M., Larrauri, A., López-Fresneña, N., Martínez de Salázar, A., Molina, J. D., Ortí-Lucas, R. M., … Mortier, P. (2023). Traumatic stress symptoms among Spanish healthcare workers during the COVID-19 pandemic: a prospective study. Epidemiology and Psychiatric Sciences, 32, e50. https://doi.org/10.1017/S2045796023000628
Solé, B., Bonnín, C. M., Radua, J., Montejo, L., Hogg, B., Jimenez, E., Reinares, M., Valls, E., Varo, C., Pacchiarotti, I., Valentí, M., Garriga, M., Torres, I., Martínez-Arán, A., Vieta, E., & Torrent, C. (2023). Long-term outcome predictors after functional remediation in patients with bipolar disorder – CORRIGENDUM. Psychological Medicine, 53(12), 5886–5886. https://doi.org/10.1017/S0033291723001538
Valli, I., Gonzalez Segura, A., Verdolini, N., Garcia‐Rizo, C., Berge, D., Baeza, I., Cuesta, M. J., Gonzalez‐Pinto, A., Lobo, A., Martinez‐Aran, A., Mezquida, G., Pina‐Camacho, L., Roldan Bejarano, A., Mas, S., McGuire, P., Bernardo, M., & Vieta, E. (2023). Obstetric complications and genetic risk for schizophrenia: Differential role of antenatal and perinatal events in first episode psychosis. Acta Psychiatrica Scandinavica, 148(1), 81–90. https://doi.org/10.1111/acps.13546
Yildiz, A., Siafis, S., Mavridis, D., Vieta, E., & Leucht, S. (2023). Comparative efficacy and tolerability of pharmacological interventions for acute bipolar depression in adults: a systematic review and network meta-analysis. The Lancet Psychiatry, 10(9), 693–705. https://doi.org/10.1016/S2215-0366(23)00199-2