Bipolar and Depressive Disorders

Mental Health

The bipolar and depressive disorders programme, characterised by a multidisciplinary approach, investigates the neurobiological and anatomofunctional mechanisms involved in the development of the disease (genetics, neuromodulators, hormone factors and neuroimaging) and its relapses, the clinical course and neuropsychological consequences, the efficacy of drug treatments and novel therapies, and psychological interventions for the early detection and relapse prevention, the therapeutic adherence enhancement; and the improvement of the effectiveness of therapeutic strategies for affective disorders. Its strategic objectives are to investigate the causes and mechanisms involved in the etiopathogenesis of bipolar and unipolar disorders and their treatment under the new paradigm of Precision Psychiatry.

Principal Investigators

Eduard Vieta

Full Professor

Technologies & Methods

  • Psychiatric assessment and treatment
  • Clinical trial design and methodology
  • Development, evaluation, and implementation of digital technologies in the field of mental health
  • Precision Psychiatry

Research Team

Antoni Benabarre

Lecturer

Iria Grande

Lecturer

Anabel Martinez-Aran

Lecturer

Marina Garriga

Postdoctoral Researcher

Diego Hidalgo

Postdoctoral Researcher

Ester Jimenez

Postdoctoral Researcher

Andrea Murru

Postdoctoral Researcher

Isabella Pacchiarotti

Postdoctoral Researcher

Carla Torrent

Postdoctoral Researcher

Marc Valenti

Postdoctoral Researcher

Gerard Anmella

Postdoctoral Researcher

Derek Clougher

Early Stage Researcher

Giovanna Fico

Postdoctoral Researcher

Anna Gimenez

Early Stage Researcher

Maria Sagué

Early Stage Researcher

Laura Montejo

Postdoctoral Researcher

Jose Sanchez-Moreno

Postdoctoral Researcher

Brisa Sole

Postdoctoral Researcher

Maria Serra-Navarro

Early Stage Researcher

Maria Florencia Forte

Early Stage Researcher

Natalia Roberto Herrero

Early Stage Researcher

Michele De Prisco

Early Stage Researcher

Vincenzo Oliva

Early Stage Researcher

Natalia E Fares-Otero

Early Stage Researcher

Ariadna Mas-Musons

Early Stage Researcher

Marta Bort

Early Stage Researcher

Lidia Ilzarbe Simorte

Early Stage Researcher

Mariadelos Angeles Botí

Early Stage Researcher

Selected publications

Anmella, G., Sanabra, M., Primé-Tous, M., Segú, X., Cavero, M., Morilla, I., Grande, I., Ruiz, V., Mas, A., Martín-Villalba, I., Caballo, A., Esteva, J.-P., Rodríguez-Rey, A., Piazza, F., Valdesoiro, F. J., Rodriguez-Torrella, C., Espinosa, M., Virgili, G., Sorroche, C., … Hidalgo-Mazzei, D. (2023). Vickybot, a Chatbot for Anxiety-Depressive Symptoms and Work-Related Burnout in Primary Care and Health Care Professionals: Development, Feasibility, and Potential Effectiveness Studies. Journal of Medical Internet Research, 25, e43293. https://doi.org/10.2196/43293

Bioque, M., Rumià, J., Roldán, P., Hidalgo-Mazzei, D., Montejo, L., Benabarre, A., Gil-Badenes, J., Tercero, J., Parellada, E., & Vieta, E. (2023). Deep brain stimulation and digital monitoring for patients with treatment-resistant schizophrenia and bipolar disorder: A case series. Revista de Psiquiatría y Salud Mental. https://doi.org/10.1016/j.rpsm.2023.05.001

Crovetto, F., Nakaki, A., Arranz, A., Borras, R., Vellvé, K., Paules, C., Boutet, M. L., Castro-Barquero, S., Freitas, T., Casas, R., Martín-Asuero, A., Oller Guzmán, T., Morilla, I., Martínez-Àran, A., Camacho, A., Pasqual, M., Izquierdo Renau, M., Pozo, Ó. J., Gomez-Gomez, A., … Gratacós, E. (2023). Effect of a Mediterranean Diet or Mindfulness-Based Stress Reduction During Pregnancy on Child Neurodevelopment. JAMA Network Open, 6(8), e2330255. https://doi.org/10.1001/jamanetworkopen.2023.30255

Fares-Otero, N. E., Alameda, L., Pfaltz, M. C., Martinez-Aran, A., Schäfer, I., & Vieta, E. (2023). Examining associations, moderators and mediators between childhood maltreatment, social functioning, and social cognition in psychotic disorders: a systematic review and meta-analysis. Psychological Medicine, 53(13), 5909–5932. https://doi.org/10.1017/S0033291723001678

Fares‐Otero, N. E., De Prisco, M., Oliva, V., Radua, J., Halligan, S. L., Vieta, E., & Martinez‐Aran, A. (2023). Association between childhood maltreatment and social functioning in individuals with affective disorders: A systematic review and meta‐analysis. Acta Psychiatrica Scandinavica, 148(2), 142–164. https://doi.org/10.1111/acps.13557

Fico, G., Janiri, D., Pinna, M., Sagué-Vilavella, M., Gimenez Palomo, A., Oliva, V., De Prisco, M., Cortez, P. G., Anmella, G., Gonda, X., Sani, G., Tondo, L., Vieta, E., & Murru, A. (2023). Affective temperaments mediate aggressive dimensions in bipolar disorders: A cluster analysis from a large, cross-sectional, international study. Journal of Affective Disorders, 323, 327–335. https://doi.org/10.1016/j.jad.2022.11.084

Giménez‐Palomo, A., Gomes‐da‐Costa, S., Borràs, R., Pons‐Cabrera, M. T., Doncel‐Moriano, A., Arbelo, N., Leyes, P., Forga, M., Mateu‐Salat, M., Pereira‐Fernandes, P. M., Benabarre, A., Pacchiarotti, I., & Vieta, E. (2023). Effects of malnutrition on length of stay in patients hospitalized in an acute psychiatric ward. Acta Psychiatrica Scandinavica, 148(4), 316–326. https://doi.org/10.1111/acps.13598

Gomes-da-Costa, S., Solé, E., Williams, E., Giménez, A., Garriga, M., Pacchiarotti, I., Vázquez, M., Cavero, M., Blanch, J., Pérez, V., Palao, D., Vieta, E., & Verdolini, N. (2023). The impact of the Catalonia Suicide Risk Code (CSRC) in a tertiary hospital: Reduction in hospitalizations and emergency room visits for any reason but not for suicide attempt. Spanish Journal of Psychiatry and Mental Health, 16(2), 68–75. https://doi.org/10.1016/j.rpsm.2021.05.004

Khanra, S., Reddy, P., Giménez-Palomo, A., Park, C. H. J., Panizzutti, B., McCallum, M., Arumugham, S. S., Umesh, S., Debnath, M., Das, B., Venkatasubramanian, G., Ashton, M., Turner, A., Dean, O. M., Walder, K., Vieta, E., Yatham, L. N., Pacchiarotti, I., Reddy, Y. C. J., … Kim, J. H. (2023). Metabolic regulation to treat bipolar depression: mechanisms and targeting by trimetazidine. Molecular Psychiatry, 28(8), 3231–3242. https://doi.org/10.1038/s41380-023-02134-8

McWhinney, S. R., Abé, C., Alda, M., Benedetti, F., Bøen, E., del Mar Bonnin, C., Borgers, T., Brosch, K., Canales-Rodríguez, E. J., Cannon, D. M., Dannlowski, U., Diaz-Zuluaga, A. M., Dietze, L. M. F., Elvsåshagen, T., Eyler, L. T., Fullerton, J. M., Goikolea, J. M., Goltermann, J., Grotegerd, D., … Hajek, T. (2023). Mega-analysis of association between obesity and cortical morphology in bipolar disorders: ENIGMA study in 2832 participants. Psychological Medicine, 53(14), 6743–6753. https://doi.org/10.1017/S0033291723000223

Nakaki, A., Crovetto, F., Urru, A., Piella, G., Borras, R., Comte, V., Vellvé, K., Paules, C., Segalés, L., Dacal, M., Gomez, Y., Youssef, L., Casas, R., Castro-Barquero, S., Martín-Asuero, A., Oller Guzmán, T., Morilla, I., Martínez-Àran, A., Camacho, A., … Gratacós, E. (2023). Effects of Mediterranean diet or mindfulness-based stress reduction on fetal and neonatal brain development: a secondary analysis of a randomized clinical trial. American Journal of Obstetrics & Gynecology MFM, 5(12), 101188. https://doi.org/10.1016/j.ajogmf.2023.101188

Portillo-Van Diest, A., Vilagut, G., Alayo, I., Ferrer, M., Amigo, F., Amann, B. L., Aragón-Peña, A., Aragonès, E., Asúnsolo Del Barco, Á., Campos, M., Del Cura-González, I., Espuga, M., González-Pinto, A., Haro, J. M., Larrauri, A., López-Fresneña, N., Martínez de Salázar, A., Molina, J. D., Ortí-Lucas, R. M., … Mortier, P. (2023). Traumatic stress symptoms among Spanish healthcare workers during the COVID-19 pandemic: a prospective study. Epidemiology and Psychiatric Sciences, 32, e50. https://doi.org/10.1017/S2045796023000628

Solé, B., Bonnín, C. M., Radua, J., Montejo, L., Hogg, B., Jimenez, E., Reinares, M., Valls, E., Varo, C., Pacchiarotti, I., Valentí, M., Garriga, M., Torres, I., Martínez-Arán, A., Vieta, E., & Torrent, C. (2023). Long-term outcome predictors after functional remediation in patients with bipolar disorder – CORRIGENDUM. Psychological Medicine, 53(12), 5886–5886. https://doi.org/10.1017/S0033291723001538

Valli, I., Gonzalez Segura, A., Verdolini, N., Garcia‐Rizo, C., Berge, D., Baeza, I., Cuesta, M. J., Gonzalez‐Pinto, A., Lobo, A., Martinez‐Aran, A., Mezquida, G., Pina‐Camacho, L., Roldan Bejarano, A., Mas, S., McGuire, P., Bernardo, M., & Vieta, E. (2023). Obstetric complications and genetic risk for schizophrenia: Differential role of antenatal and perinatal events in first episode psychosis. Acta Psychiatrica Scandinavica, 148(1), 81–90. https://doi.org/10.1111/acps.13546

Yildiz, A., Siafis, S., Mavridis, D., Vieta, E., & Leucht, S. (2023). Comparative efficacy and tolerability of pharmacological interventions for acute bipolar depression in adults: a systematic review and network meta-analysis. The Lancet Psychiatry, 10(9), 693–705. https://doi.org/10.1016/S2215-0366(23)00199-2