Hair cell damage mechanisms in the zebrafish lateral line
Mechanisms and physiological impact of hair cell loss in the mammalian vestibular system
Mechanisms underlying the light response in photoreceptor cells of the retina, light adaptation and inherited blindness.
This programme focuses on investigating genetic and acquired causes of sensory disorders to identify potential targets for treatment as well as for preservation of sensory functions during ageing. Animal models and first-line methodologies, such as super-resolution fluorescence microscopy, RNA-seq and proteomics, are used to identify the cellular and molecular mechanisms leading to sensory loss.