Principal Investigators



Clinical and experimental research in Parkinson’s disease and other neurodegenerative movement disorders

Research team


Eduard Tolosa

Full Professor


Alicia Garrido

Medical Assistant Professor


Maria J Marti

Medical Assistant Professor


Esteban Muñoz

Medical Assistant Professor


Almudena Sanchez

Medical Assistant Professor


Francesc Valldeoriola

Medical Assistant Professor


Mario Ezquerra

Postdoctoral Researcher


Ruben Fernandez

Postdoctoral Researcher


Ana Camara

Early Stage Researcher


Celia Painous

Early Stage Researcher


Sandra Perez

Early Stage Researcher


Manel Fernandez



Laura Maragall



Pilar Santacruz


Research Interest


Molecular pathophysiological mechanisms including genetics and epigenetics, biomarkers, both biochemical (chiefly CSF) and imaging and experimental therapies (clinical trials) in Parkinson’s disease and other movement disorders.

Technologies & Methods


  • Disease/disorder characterisation: Endophenotypification studies
  • Assessment of new treatments: Clinical trials, non-dopa agents
  • Methods for diagnostic: Cerebrospinal fluid (CSF) and imaging biomarkers
  • Clinical data: Collaborative clinical registries
  • Development of new tools / technologies / computational methods: Implement new CSF (RTQuIC) and PET (foreseeably in the future tau and eventually alpha-synuclein) markers

Active Projects


    • Plataforma Traslacional para la AMS: Descubriendo mecanismos patológicos y nuevas dianas terapéuticas: PTra- ADPT. Instituto de Salud Carlos III. AC21_2/00018. Yaroslau Compta.


    • Psp registry: clinical cohort study with biomarkers study of prediagnostic cases and health education program in established disease. Fundació La Marató de TV3. 202009-10. Yaroslau Compta.


    • 3 Confidential agreements.

Selected Publications


    • Cámara, A., Compta, Y., Pérez-Soriano, A., Montagut, N., Baixauli, M., Maragall, L., Ludeña, E., Lopez de Los Reyes, J. C., Peri-Cusi, L., Fernández, N., Villote, S., Ahuir, M., Grau, A., Caballol, N., Buongiorno, M., Pont-Sunyer, C., Puente, V., Giraldo, D. M., de Fabregues, O., Garrido, A., … Martí, M. J. (2021). Effects of COVID -19 pandemic and lockdown on people with multiple system atrophy participating in a therapeutic education program. Parkinsonism & Related Disorders, 86, 78–80.


    • Esteller, D., Modreanu, R., Cerquera-Cleves, S. C., Sánchez-Gómez, A., Fernández, M., Cámara, A., & Compta, Y. (2021). Cross-sectional associations of cerebrospinal α-synuclein, tau and amyloid-β with dyskinesias, motor fluctuations, non-motor symptoms in a cohort of Parkinson’s disease patients. Journal of the Neurological Sciences, 430, 120033.


    • Guasp, M., Molina-Porcel, L., Painous, C., Caballol, N., Camara, A., Perez-Soriano, A., Sánchez-Gómez, A., Garrido, A., Muñoz, E., Marti, M. J., Valldeoriola, F., Grau, O., Gelpí, E., Respondek, G., Höglinger, G. H., & Compta, Y. (2021). Association of PSP phenotypes with survival: A brain-bank study. Parkinsonism & Related Disorders, 84, 77–81.


    • Inguanzo, A., Segura, B., Sala-Llonch, R., Monte-Rubio, G., Abos, A., Campabadal, A., Uribe, C., Baggio, H. C., Marti, M. J., Valldeoriola, F., Compta, Y., Bargallo, N., & Junque, C. (2021). Impaired Structural Connectivity in Parkinson’s Disease Patients with Mild Cognitive Impairment: A Study Based on Probabilistic Tractography. Brain Connectivity, 11(5), 380–392.


    • Oltra, J., Campabadal, A., Segura, B., Uribe, C., Marti, M. J., Compta, Y., Valldeoriola, F., Bargallo, N., Iranzo, A., & Junque, C. (2021). Disrupted functional connectivity in PD with probable RBD and its cognitive correlates. Scientific Reports, 11(1), 24351.


    • Sánchez-Gómez, A., Compta, Y., & Martí, M. J. (2021). Insulinreleasing or insulin-sensitizing drugs in Parkinson’s disease? Choosing a pathway. Parkinsonism & Related Disorders, 93, 109–110.


    • Sánchez-Gómez, A., Díaz, Y., Duarte-Salles, T., Compta, Y., & Martí, M. J. (2021). Prediabetes, type 2 diabetes mellitus and risk of Parkinson’s disease: A population-based cohort study. Parkinsonism & Related Disorders, 89, 22–27.