CLINICAL AND EXPERIMENTAL RESEARCH IN PARKINSON’S DISEASE AND OTHER NEURODEGENERATIVE MOVEMENT DISORDERS

Principal Investigators

YAROSLAU COMPTA

Neurologist

Clinical and experimental research in Parkinson’s disease and other neurodegenerative movement disorders

Research team

 

Eduard Tolosa

Full Professor

 

Alicia Garrido

Medical Assistant Professor

 

Maria J Marti

Medical Assistant Professor

 

Esteban Muñoz

Medical Assistant Professor

 

Almudena Sanchez

Medical Assistant Professor

 

Francesc Valldeoriola

Medical Assistant Professor

 

Mario Ezquerra

Postdoctoral Researcher

 

Ruben Fernandez

Postdoctoral Researcher

 

Ana Camara

Early Stage Researcher

 

Celia Painous

Early Stage Researcher

 

Sandra Perez

Early Stage Researcher

 

Manel Fernandez

Technician

 

Laura Maragall

Others

 

Pilar Santacruz

Others

Research Interest

 

Molecular pathophysiological mechanisms including genetics and epigenetics, biomarkers, both biochemical (chiefly CSF) and imaging and experimental therapies (clinical trials) in Parkinson’s disease and other movement disorders.

Technologies & Methods

 

  • Disease/disorder characterisation: Endophenotypification studies
  • Assessment of new treatments: Clinical trials, non-dopa agents
  • Methods for diagnostic: Cerebrospinal fluid (CSF) and imaging biomarkers
  • Clinical data: Collaborative clinical registries
  • Development of new tools / technologies / computational methods: Implement new CSF (RTQuIC) and PET (foreseeably in the future tau and eventually alpha-synuclein) markers

Featured Projects

 

    • Amplificación de autoagregación de alfa-sinucleína y 4R-tau en tejido cerebral y líquido cerebrospinal mediante RTQuIC como biomarcador diferencial de parkinsonismos degenerativos. Fondo de Investigaciones Sanitarias de la Seguridad Social (FISS). PI17/00096. Yaroslau Compta i Maria J Marti

 

    • Estudi de cohort clínic, recerca de biomarcadors i programa d’educació sanitària. Fundació La Marató de TV3. 202009-10. Yaroslau Compta

 

    • FAIR-PARK-II A multicentre, parallel group, randomized, placebo-controlled trial of deferiprone (DFP) 15 mg/kg BID. European Commission. EudraCT 2015 003679-31. Yaroslau Compta

Featured Publications

 

    • Painous, C., Martí, M. J., Simonet, C., Garrido, A., Valldeoriola, F., Muñoz, E., Cámara, A., & Compta, Y. (2020). Prediagnostic motor and non-motor symptoms in progressive supranuclear palsy: The step-back PSP study. Parkinsonism & Related Disorders, 74, 67–73. https://doi.org/https://doi.org/10.1016/j.parkreldis.2020.03.003

 

    • Compta, Y., Dias, S. P., Giraldo, D. M., Pérez-Soriano, A., Muñoz, E., Saura, J., Fernández, M., Bravo, P., Cámara, A., Pulido-Salgado, M., Painous, C., Ríos, J., Martí, M. J., & CMSAR consortium (2019). Cerebrospinal fluid cytokines in multiple system atrophy: A cross-sectional Catalan MSA registry study. Parkinsonism & Related Disorders, 65, 3–12. https://doi.org/10.1016/j.parkreldis.2019.05.040

 

    • Compta, Y., Giraldo, D. M., Muñoz, E., Antonelli, F., Fernández, M., Bravo, P., Soto, M., Cámara, A., Torres, F., Martí, M. J., & Catalan MSA Registry (CMSAR) (2018). Cerebrospinal fluid levels of coenzyme Q10 are reduced in multiple system atrophy. Parkinsonism & Related Disorders, 46, 16–23. https://doi.org/10.1016/j.parkreldis.2017.10.010

 

    • Höglinger, G. U., Respondek, G., Stamelou, M., Kurz, C., Josephs, K. A., Lang, A. E., Mollenhauer, B., Müller, U., Nilsson, C., Whitwell, J. L., Arzberger, T., Englund, E., Gelpi, E., Giese, A., Irwin, D. J., Meissner, W. G., Pantelyat, A., Rajput, A., van Swieten, J. C., Troakes, C., … Movement Disorder Society-endorsed PSP Study Group (2017). Clinical diagnosis of progressive supranuclear palsy: The movement disorder society criteria. Movement Disorders, 32(6), 853–864. https://doi.org/10.1002/mds.26987

 

    • Compta, Y., Valente, T., Saura, J., Segura, B., Iranzo, Á., Serradell, M., Junqué, C., Tolosa, E., Valldeoriola, F., Muñoz, E., Santamaria, J., Cámara, A., Fernández, M., Fortea, J., Buongiorno, M., Molinuevo, J. L., Bargalló, N., & Martí, M. J. (2015). Correlates of cerebrospinal fluid levels of oligomeric- and total-α-synuclein in premotor, motor and dementia stages of Parkinson’s disease. Journal of Neurology, 262(2), 294–306. https://doi.org/10.1007/s00415-014-7560-z

 

    • Sabater, L., Gaig, C., Gelpi, E., Bataller, L., Lewerenz, J., Torres-Vega, E., Contreras, A., Giometto, B., Compta, Y., Embid, C., Vilaseca, I., Iranzo, A., Santamaría, J., Dalmau, J., & Graus, F. (2014). A novel non-rapid-eye movement and rapid-eye-movement parasomnia with sleep breathing disorder associated with antibodies to IgLON5: a case series, characterisation of the antigen, and post-mortem study. The Lancet. Neurology, 13(6), 575–586. https://doi.org/10.1016/S1474-4422(14)70051-1

 

    • Compta, Y., Pereira, J. B., Ríos, J., Ibarretxe-Bilbao, N., Junqué, C., Bargalló, N., Cámara, A., Buongiorno, M., Fernández, M., Pont-Sunyer, C., & Martí, M. J. (2013). Combined dementia-risk biomarkers in Parkinson’s disease: a prospective longitudinal study. Parkinsonism & Related Disorders, 19(8), 717–724. https://doi.org/10.1016/j.parkreldis.2013.03.009

 

    • Compta, Y., Parkkinen, L., O’Sullivan, S. S., Vandrovcova, J., Holton, J. L., Collins, C., Lashley, T., Kallis, C., Williams, D. R., de Silva, R., Lees, A. J., & Revesz, T. (2011). Lewy- and Alzheimer-type pathologies in Parkinson’s disease dementia: which is more important?. Brain, 134(Pt 5), 1493–1505. https://doi.org/10.1093/brain/awr031

 

    • Compta, Y., Santamaria, J., Ratti, L., Tolosa, E., Iranzo, A., Muñoz, E., Valldeoriola, F., Casamitjana, R., Ríos, J., & Marti, M. J. (2009). Cerebrospinal hypocretin, daytime sleepiness and sleep architecture in Parkinson’s disease dementia. Brain, 132(Pt 12), 3308–3317. https://doi.org/10.1093/brain/awp263

 

    • Compta, Y., Martí, M. J., Ibarretxe-Bilbao, N., Junqué, C., Valldeoriola, F., Muñoz, E., Ezquerra, M., Ríos, J., & Tolosa, E. (2009). Cerebrospinal tau, phospho-tau, and beta-amyloid and neuropsychological functions in Parkinson’s disease. Movement Disorders, 24(15), 2203–2210. https://doi.org/10.1002/mds.22594

Knowledge transfer & Innovation

 

    • Diagnostic Method for Multiple System Atrophy. P4761EP00