MOLECULAR AND CELLULAR NEUROBIOTECHNOLOGY

Principal Investigators

Jose Antonio Del Rio

Full Professor

Molecular and cellular neurobiotechnology

Research team

 

Rosalina Gavin

Associate Professor

 

Vanesa Gil

Assistant Professor

 

Arnau Hervera

Postdoctoral Researcher

 

Sara Martinez

Postdoctoral Researcher

 

Ana Lopez-Mengual

Early Stage Researcher

 

Francina Mesquida

Early Stage Researcher

 

Julia Sala

Early Stage Researcher

 

Karen Wells

Early Stage Researcher

 

Miriam Segura

Technician

Research Interest

 

This programme is interested in understanding the processes of development, neuronal plasticity and neurodegeneration of the central nervous system. The main objective is to determine the biochemical function of genes overexpressed during development and neurodegeneration and their particular roles in the central nervous system. Thus, current experiments focus on: the role of angiogenic mechanical factors during cortical development, developing new approaches to enhance axon regeneration after injury, characterisation new biomarkers and detection methods for Alzheimer and Parkinson diseases and characterisation of the role of the PrPc in neurodegeneration.

Technologies & Methods

 

  • Cell culture methods
  • Organotypic slices
  • Optogenetics and chemogenetics methods in vitro and in vivo
  • Calcium imaging and neural network analysis
  • Lab-on-chip- technology
  • Microfluidics blood-brain barrier models
  • Estereotaxic and surgical methods
  • Behavioural analysis of mice models of neurodegeneration

Featured Projects

 

    • Análisis celular y molecular de la siembra y progresión de tau en modelos animales y celulares de distintas taupatías humanas. Consorcio CIBER del área de Enfermedades Neurodegenerativas. CNED-2018-2. Jose Antonio del Rio

 

    • Bases cel·lulars i moleculars en neurodegeneració i neuroregeneració (CMBNN). Agència de Gestió d’Ajuts Universitaris i de Recerca. 2017SGR648. Jose Antonio del Rio

 

    • Enfermedades neurodegenerativas (CIBERNED). Instituto de Salud Carlos III. Ministerio de Ciencia e Innovación. CB07/05/2011. Jose Antonio del Rio

 

    • Modulation of Tau seeding and pathology in tauopathies by BBB-nanocarriers, epitope selective vaccination and ectoPrP Tau receptor bodies (STOPTauPATHOL). Fundació Caixa de Pensions ‘La Caixa’. HR18-00452. Jose Antonio del Rio

 

    • Nuevas aproximaciones para entender las funciones de la PrPC y miembros secretables de semaforinas durante el desarrollo del hipocampo y en neurotransmisión. Ministerio de Ciencia, Innovación y Universidades. RTI2018-099773-B-I00. Jose Antonio del Rio

Featured Publications

 

    • Duran, J., Hervera, A., Markussen, K. H., Varea, O., López-Soldado, I., Sun, R. C., Del Río, J. A., Gentry, M. S., & Guinovart, J. J. (2021). Astrocytic glycogen accumulation drives the pathophysiology of neurodegeneration in Lafora disease. Brain. Advance online publication. https://doi.org/10.1093/brain/awab110

 

 

    • Ferrer, I., Andrés-Benito, P., Zelaya, M. V., Aguirre, M., Carmona, M., Ausín, K., Lachén-Montes, M., Fernández-Irigoyen, J., Santamaría, E., & Del Rio, J. A. (2020). Familial globular glial tauopathy linked to MAPT mutations: molecular neuropathology and seeding capacity of a prototypical mixed neuronal and glial tauopathy. Acta Neuropathologica, 139(4), 735–771. https://doi.org/10.1007/s00401-019-02122-9

 

    • Sala-Jarque, J., Mesquida-Veny, F., Badiola-Mateos, M., Samitier, J., Hervera, A., & Del Río, J. A. (2020). Neuromuscular Activity Induces Paracrine Signaling and Triggers Axonal Regrowth after Injury in Microfluidic Lab-On-Chip Devices. Cells, 9(2), 302. https://doi.org/10.3390/cells9020302

 

    • Del Rio, J. A., & Ferrer, I. (2020). Potential of Microfluidics and Lab-on-Chip Platforms to Improve Understanding of “prion-like” Protein Assembly and Behavior. Frontiers in Bioengineering and Biotechnology, 8, 570692. https://doi.org/10.3389/fbioe.2020.570692

 

    • Hervera, A., Zhou, L., Palmisano, I., McLachlan, E., Kong, G., Hutson, T. H., Danzi, M. C., Lemmon, V. P., Bixby, J. L., Matamoros-Angles, A., Forsberg, K., De Virgiliis, F., Matheos, D. P., Kwapis, J., Wood, M. A., Puttagunta, R., Del Río, J. A., & Di Giovanni, S. (2019). PP4-dependent HDAC3 dephosphorylation discriminates between axonal regeneration and regenerative failure. The EMBO Journal, 38(13), e101032. https://doi.org/10.15252/embj.2018101032

 

    • Urrea, L., Segura-Feliu, M., Masuda-Suzukake, M., Hervera, A., Pedraz, L., García Aznar, J. M., Vila, M., Samitier, J., Torrents, E., Ferrer, I., Gavín, R., Hagesawa, M., & Del Río, J. A. (2018). Involvement of Cellular Prion Protein in α-Synuclein Transport in Neurons. Molecular Neurobiology, 55(3), 1847–1860. https://doi.org/10.1007/s12035-017-0451-4

 

    • Mata, A., Gil, V., Pérez-Clausell, J., Dasilva, M., González-Calixto, M. C., Soriano, E., García-Verdugo, J. M., Sanchez-Vives, M. V., & Del Río, J. A. (2018). New functions of Semaphorin 3E and its receptor PlexinD1 during developing and adult hippocampal formation. Scientific Reports, 8(1), 1381. https://doi.org/10.1038/s41598-018-19794-0

 

    • Hervera, A., De Virgiliis, F., Palmisano, I., Zhou, L., Tantardini, E., Kong, G., Hutson, T., Danzi, M. C., Perry, R. B., Santos, C., Kapustin, A. N., Fleck, R. A., Del Río, J. A., Carroll, T., Lemmon, V., Bixby, J. L., Shah, A. M., Fainzilber, M., & Di Giovanni, S. (2018). Reactive oxygen species regulate axonal regeneration through the release of exosomal NADPH oxidase 2 complexes into injured axons. Nature Cell Biology, 20(3), 307–319. https://doi.org/10.1038/s41556-018-0039-x