Principal Investigators

Joan Guardia-Olmos

Full professor

Quantitative neuroscience

Research team


Maribel Pero

Full Professor


Vicenç Quera

Full Professor


Francesc Salvador

Full Professor


Antonio Solanas

Full Professor


Jordi Galbany



David Leiva

Associate Professor


Rumen Rumenov

Associate Professor


Maria Carbo

Associate Professor


Ruth Dolado

Assistant Professor


Sonia Benitez



Laia Farras



Cristina Castañe

Early Stage Researcher


Alvaro Lopez

Early Stage Researcher


Elisabet Gimeno

Early Stage Researcher


Nuria Mancho

Early Stage Researcher


Marc Montala

Early Stage Researcher

Research Interest


The study of brain connectivity is one of the main challenges when studying the active brain. Brain connectivity is operationally defined as the estimation of the relation between brain areas (regions of interest, ROIs, or Volumes of interest, VOIs); these relations are established when a specific cognitive task is being solved or when resting. In order to estimate the connectivity, different brain signals can be used, each of which has different neurofucntional properties. One of the signals showing great ability to represent the active brain is the BOLD signal, obtained when using functional magnetic resonance imaging (fMRI). What is registered is the modification of the magnetic field that takes place due to the increment of the presence of oxygen is certain brain areas when these are activated during a cognitive task. When the brain is resting, the signal shows the basal state used as a reference.

Technologies & Methods


  • Generation of statistical advanced models applied to the big data structures and brain signal
  • Psychometric technology
  • Advanced Multivariate Analysis

Active Projects


    • Doctorats industrials 2019. Empresa: Consorci Sant Gregori. Agència de Gestió d’Ajuts Universitaris i de Recerca. 2019DI69. Joan Guardia.


    • Indicadores estadísticos para el estudio de redes de conectividad cerebral en registros de resonancia magnética funcional (FMRI) y su aplicación para el diagnostico del deterioro cognitivo. Ministerio de Ciencia, Innovación y Universidades. PGC2018-095829-B-I00. Joan Guardia.


    • Psicologia Quantitativa. Agència de Gestió d’Ajuts Universitaris i de Recerca. 2017SGR269. Joan Guardia.


    • 3 Confidential agreements

Selected Publications


    • Cañete-Massé, C., Carbó-Carreté, M., Figueroa-Jiménez, M. D., Oviedo, G. R., Guerra-Balic, M., Javierre, C., Peró-Cebollero, M., & Guàrdia-Olmos, J. (2021). Confirmatory factor analysis with missing data in a small sample: cognitive reserve in people with Down Syndrome. Quality & Quantity. https://doi.org/10.1007/s11135-021-01264-x


    • Cañete-Massé, C., Carbó-Carreté, M., Peró-Cebollero, M., & Guàrdia-Olmos, J. (2021). Task-Related Brain Connectivity Activation Functional Magnetic Resonance Imaging in Intellectual Disability Population: A Meta-Analytic Study. Brain Connectivity, 11(10), 788–798. https://doi.org/10.1089/brain.2020.0911


    • Delfa-Lobato, L., Guàrdia-Olmos, J., & Feliu-Torruella, M. (2021). Benefits of Cultural Activities on People With Cognitive Impairment: A Systematic Review. Frontiers in Psychology, 12, 762392. https://doi.org/10.3389/fpsyg.2021.762392


    • Figueroa-Jiménez, M. D., Cañete-Massé, C., Carbó-Carreté, M., Zarabozo-Hurtado, D., & Guàrdia-Olmos, J. (2021). Structural equation models to estimate dynamic effective connectivity networks in resting fMRI. A comparison between individuals with Down syndrome and controls. Behavioural Brain Research, 405, 113188. https://doi.org/10.1016/j.bbr.2021.113188


    • Figueroa-Jimenez, M. D., Carbó-Carreté, M., Cañete-Massé, C., Zarabozo-Hurtado, D., Peró-Cebollero, M., Salazar-Estrada, J. G., & Guàrdia-Olmos, J. (2021). Complexity Analysis of the Default Mode Network Using Resting-State fMRI in Down Syndrome: Relationships Highlighted by a Neuropsychological Assessment. Brain Sciences, 11(3), 311. https://doi.org/10.3390/brainsci11030311


    • Méndez-López, C., Pereda, N., & Guilera, G. (2021). Lifetime poly-victimization and psychopathological symptoms in Mexican adolescents. Child Abuse & Neglect, 112, 104883. https://doi.org/10.1016/j.chiabu.2020.104883


    • Oviedo, G. R., Garcia-Retortillo, S., Carbó-Carreté, M., Guerra-Balic, M., Balagué, N., Javierre, C., & Guàrdia-Olmos, J. (2021). Cardiorespiratory Coordination During Exercise in Adults with Down Syndrome. Frontiers in Physiology, 12, 704062. https://doi.org/10.3389/fphys.2021.704062


    • Pérez-González, A., Vilajoana-Celaya, J., & Guàrdia-Olmos, J. (2021). Alzheimer’s Disease Caregiver Characteristics and Their Relationship with Anticipatory Grief. International Journal of Environmental Research and Public Health, 18(16), 8838. https://doi.org/10.3390/ijerph18168838