Antonio Strafella | University of Toronto, Toronto, ON, Canada
Thilo Van Eimeren | University of Cologne, Germany
Differential diagnoses between Parkinsonian syndromes pose significant challenges for clinicians as clinical manifestations can overlap and there are no gold standard biomarkers. Multimodal translational approaches from novel molecular makers using positron emission tomography (PET) to the brain connectomics by means of magnetic resonance imaging (MRI) could help to elucidate the underlying brain mechanisms of parkinsonisms and their clinical prognoses.
Dr. Raquel Jimenez Pasalodos - Universidad de Valladolid and Universitat de Barcelona (ERC Artsoundscapes project)
The poster of this talk can be downloaded from here
Tobias Reichenbach, PhD | Imperial College London
Understanding speech in noisy backgrounds requires selective attention to a particular speaker. Humans excel at this challenging task, while current speech recognition technology still struggles when background noise is loud. The neural mechanisms by which we process speech remain, however, poorly understood, not least due to the complexity of natural speech. Here we describe recent progress obtained through applying machine-learning to neuroimaging data of humans listening to speech in different types of background noise. In particular, we develop statistical models to relate characteristic features of speech such as pitch, amplitude fluctuations and linguistic surprisal to neural measurements. We find neural correlates of speech processing both at the subcortical level, related to the pitch, as well as at the cortical level, related to amplitude fluctuations and linguistic structures. We also show that some of these measures allow to diagnose disorders of consciousness. Our findings may be applied in smart hearing aids that automatically adjust speech processing to assist a user, as well as in diagnostics of brain disorders.
Chris Butler |Imperial College London/University of Oxford
Memory impairment is common in neurological disease and is often associated with hippocampal pathology. Pure hippocampal amnesia is, however, relatively rare and its underlying mechanisms are controversial. I will discuss research from patients with both transient and persistent forms of amnesia, which provide insights into memory impairment more broadly and from whom important clinical lessons can be learned. In particular, I will argue that many neuropsychological tests of memory are neither sensitive nor specific to hippocampal disease. Instead, we should be measuring forgetting over prolonged periods of time. Accelerated long-term forgetting is a novel and highly sensitive cognitive marker of preclinical Alzheimer’s disease.
Dr. Martijn Wokke |The City University of New York (USA), and The University of Cambridge (UK)
Manuel Mameli, PhD - Université de Lausane
To delineate the neuronal circuits underlying aversion and reward, and their implications in neuropsychiatric disorders is a current hot-topic in neuroscience. The Mameli’s lab aims to decipher the neurobiology of motivation and provide knowledge for disorders including addiction and depression by using different approaches such as electrophysiology, optogenetics, rodent behavior and molecular biology.
10th International Meeting on Neurocanthocytosis Syndromes
Hotel Alimara, March 25-27, 2020, Barcelona, Spain