Experimental Neurology

Research groups

Yaroslau Compta
Raquel Sanchez-Valle
Veronica Brito, Silvia Gines, Cristina Malagelada, Eulalia Marti, Esther Perez Navarro
Carme Junque, Marina Lopez-Sola, Barbara Segura, Guadalupe Soria, Roser Sala Llonch
Jordi Alberch, Albert Giralt, Merce Masana, Manuel Rodriguez
Isidro Ferrer
Josep Dalmau, Albert Saiz

Representative of the research area

Dr. Yaroslau Compta

ycompta@ub.edu

Research in this area focuses on the study of the nervous system in normal conditions and during neurologic disorders in preclinical stages to provide information for diagnosis, prevention and treatment for neurological diseases.

 

Neurodegenerative diseases are usually linked with aging. Thus, nowadays there is an important increase in these disorders with a strong social and economical impact in our society. Unfortunately, the majority of therapeutic interventions available are merely symptomatic, often with very limited response, whereas disease-modifying and neuroprotective or neuroregenerative treatments are only experimental with precedents in human clinical trials having been unsuccessful so far. 

 

The research area of Experimental Neurology is focused on the study of the nervous system in normal conditions and during neurological disorders.  A close collaboration between basic neuroscientists and clinical neurologists is already established in the Institute of Neurosciences . The Institute, together with the university hospitals, provides a good environment to perform studies about the correlation between genetic markers, cerebrospinal spinal fluid biomarkers and structural, functional and molecular imaging in patients with movement disorders, dementia, autoimmune synaptic disorders and other neurological disorders. Furthermore, the study of the molecular and biological bases of Alzheimer’s disease, Parkinson’s disease, Huntington’s chorea, and multiple sclerosis in preclinical stages can provide information for diagnosis, prevention and treatment for these neurological diseases.

Featured projects

 

  • Estudi de cohort clínic, recerca de biomarcadors i programa d’educació sanitària. Fundació La Marató de TV3. 202009-10. Yaroslau Compta
  • Dominantly Inherited Alzheimer Network (DIAN). National Institutes of Health (NIH). UF1 AG032438. Raquel Sanchez-Valle
  • Gliotransmitters and cannabinoid receptors at the hub of cognitive and synaptic plasticity impairments in Huntington’s disease. Fundació La Marató de TV3. Marato/2-02013-30-31-32. Silvia Gines
  • Phospho-proteome analysis of PBMCs in LRRK2 mutation carriers: expansion & validation of findings of the Barcelona LRRK2 Biorepository. Michael J. Fox Foundation for Parkinson’s research. Cristina Malagelada
  • COVID19 and brain: cognition and mental health (DIANA). Pandemies 2020. Generalitat de Catalunya. 2020PANDE00053. Carme Junque
  • Definiendo el rol de la familia Ikaros en la esquizofrenia (DISC). RETOS. MINECO. RTI2018-094678-A-100. Albert Giralt
  • Non-invasive dynamic neural control by laser-based technology (NEUROPA). FET-Open (H2020). Grant agreement 863214. Merce Masana.
  • A Translational Model of Antibody-mediated Synaptic Disease: Symptoms, Neuronal Circuits, and the Mechanisms of Memory Loss and Recovery. Fundació Caixa de Pensions ‘La Caixa’. HR17-00149. Josep Dalmau
  • Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)
  • Network Center for Biomedical Research in Epidemiology and Public Health (CIBERESP)