Experimental Neurology

Research groups

CELLULAR AND MOLECULAR BASIS OF HUNTIGTON’S DISEASE AND OTHER DISORDERS OF THE BASAL GANGLIA

Parkinson disease and other neurodegenerative movement disorders: clinical and experimental research

IMMUNOPATHOGENESIS OF PARANEOPLASTIC NEUROLOGIC SYNDROME

Pathogenesis of immune-mediated neuronal disorders

Neuropathology

NEUROIMAGING IN DEGENERATIVE DISORDERS (CJNEUROLAB)

MALAGELADA’S LAB

ALZHEIMER’S DISEASE AND OTHER COGNITIVE DISORDERS GROUP

Representative of the research area

Dr. Compta Hirnyj, Yaroslau

ycompta (at) ub.edu

Neurodegenerative diseases are usually linked with aging. Thus, nowadays there is an important increase in these disorders with a strong social and economical impact in our society.

 

Unfortunately, the majority of therapeutic interventions available are merely symptomatic, often with very limited response, whereas disease-modifying and neuroprotective or neuroregenerative treatments are only experimental with precedents in human clinical trials having been unsuccessful so far. 

 

The research area of Experimental Neurology is focused on the study of the nervous system in normal conditions and during neurologic disorders.  A close collaboration between basic neuroscientists and clinical neurologists is already established in the Institute of Neurosciences . The Institute, together with the university hospitals, provides a good environment to perform studies about the correlation between genetic markers, cerebrospinal spinal fluid biomarkers and structural, functional and molecular imaging in patients with movement disorders, dementia, autoimmune synaptic disorders and other neurological disorders. Furthermore, the study of the molecular and biological bases of Alzheimer’s disease, Parkinson’s disease, Huntington’s chorea, and multiple sclerosis in preclinical stages can provide information for diagnosis, prevention and treatment for these neurological diseases.

Projects

 

  • Red de Investigación Transfronteriza en Enfermedades Priónicas Humanas y Animales (REDPRION). EFA148/16 REDPRION. Ferrer, Isidro. Unió Europea POCTEFA (Interreg V-A España-Francia-Andorra)
  • Modulación de la dinámica de las redes neuronales como estrategia terapéutica para recuperar la disfunción de los ganglios basales en las enfermedades del movimiento. SAF2017-88076-R. Alberch, Jordi. Ministerio de Economia y Competitividad
  • Fenotipos cognitivos en la enfermedad de Parkinson mediante la identificación de patrones de neuroimagen multimodal. PSI2017-86930-P. Junque, Carme. Ministerio de Economia y Competitividad
  • ¿La proteína RTP801/REDD1 media la disfunción sináptica en procesos neurodegenerativos?. SAF2017-88812-R. Malagelada, Cristina. Ministerio de Economia y Competitividad