Pathophysiology of Nervous System Disease

Research groups

Fernando Aguado, Francesc X. Soriano
Alejandro Barrallo-Gimeno, Jordi Llorens, Ana Mendez
Eduardo Soriano, Marta Pascual
Juan Blasi, Artur Llobet,Carles Solsona
Jose Antonio Del Rio
Raul Estevez
Sandra Acosta, Soledad Alcantara, Alberto Ortega
Jaume del Valle, Christian Griñan-Ferre, Gemma Navarro, Merce Pallas, Carme Pelegri, Jordi Vilaplana
Xavier Altafaj, Gerard Callejo, Nuria Comes, Xavier Gasull, David Soto, Mar Puigdellivol
Antoni Camins, Carme Auladell
Ester Aso, Jordi Bonaventura, Francisco Ciruela, Victor Fernandez-Duenas
Josep M. Canals, Petia Radeva, Daniel Tornero, Daniel del Toro

Representative of the research area

Prof. Mercè Pallas Lliberia

pallas (at)

Research in this area focuses on defining the molecular and cellular mechanisms involved in brain function during development and adulthood, in normal and pathological conditions.


The study of the pathophysiology of nervous system diseases is an important challenge in Biomedicine to develop new successful therapies. Neurological and psychiatric disorders can disrupt molecular pathways, synapses, neuronal and glial subpopulations, and local circuits in specific brain regions, as well as higher-order neural networks. Therefore, research must range from the study of large-scale brain network alterations to the microscopic and/or genetic abnormalities. Improving our knowledge of the pathophysiology of these conditions will enable not only to identify new potential therapeutic targets but also biomarkers, whose usefulness can range from detecting diseases in very early stages more likely to respond to disease-modifying treatments than advanced stages, to differentiate among similar conditions and to monitor response to treatments.


Research in this area focuses on defining the pathophysiological mechanisms involved in the loss of normal and neuronal plasticity related to these diseases. A deeper understanding of neuronal connectivity and dynamics, signaling molecules, cell-cell interaction and epigenetic factors in the nervous system will enable us to devise new pharmacological targets for therapeutic strategies to prevent or delay nervous system diseases. 


Another therapeutic approach for nervous system disorders is neuroregenerative medicine. The institute is also interested in mimicking neural development on stem cells for replacing strategies as new therapies for diseases affecting the brain and spinal cord. 


Thus, the current structure and expertise of the Institute of Neurosciences constitute the best environment to conduct multidisciplinary and translational research to find therapeutic approaches for motor and cognitive dysfunctions.

Featured projects


  • Recerca centrada en el pacient: estudi de les necessitats del pacient, fenotipació clínica i patogènesi molecular en la Neurofibromatosi Tipus 2. Fundació La Marató de TV3. 20207-30-31. Jordi Llorens
  • Papel de la proteina de matriz extracelular Reelina en plasticidad neural y en la enfermedad de Alzheimer. MCINN. PID2019-106764RB-C21. Eduardo Soriano i Lluis Pujada
  • Modulation of Tau seeding and pathology in tauopathies by BBB-nanocarriers, epitope selective vaccination and ectoPrP Tau receptor bodies (STOPTauPATHOL). Fundació Caixa de Pensions ‘La Caixa’. HR18-00452. Jose Antonio del Rio
  • Regulación de canales de cloruro en salud y enfermedad. MICINN. RTI2018-093493-B-I00. Raul Estevez.
  • Modulation of soluble epoxide hydrolase (sEH) in brain and peripheral tissues: role of the intestinal-brain axis in neurodegeneration. Ministerio de Ciencia Innovación y Universidades. PID2019-106285RB-C21. Merce Pallas
  • In vitro Study of Neurodevelopment in Huntington’s disease. CHDI Foundation Inc. A14079. Josep M. Canals
  • Nuevos mecanismos de migración neuronal implicados en el plegamiento de la corteza cerebral. Ministerio de Ciencia Innovación y Universidades. RTI2018-095580-A-100. Daniel del Toro
  • Network Center for Biomedical Research in Neurodegenerative Diseases (CIBERNED)
  • Network Center for Biomedical Research in Rare Diseases (CIBERER)